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10.1016/j.transci.2021.103197 http://scihub22266oqcxt.onion/10.1016/j.transci.2021.103197 34175195!ä!34175195 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34175195.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Transfus+Apher+Sci 2021 ; 60 (5): 103197 Nephropedia Template TP {{tp|p=34175195|t=2021. Cyclophosphamide plus etoposide is a safe and effective mobilization regimen in patients with multiple myeloma |pdf=|usr=}}{{34175195}} gab.com Text Cyclophosphamide plus etoposide is a safe and effective mobilization regimen in patients with multiple myeloma JO: Transfus Apher Sci http://www.kidney.de/pget.php?&tw=1&pmid=34175195 #FOAvip High-dose chemotherapy followed by autologous stem cell transplantation is a major component in the treatment of patients with multiple myeloma. As a prerequisite, the successful collection of a sufficient number of viable peripheral blood hematopoietic CD34+ cells is critical. A common standard protocol for mobilization is currently not defined and critically discussed especially in German-speaking Europe. In times of the Covid-19 pandemic, safe and effective strategies have to be chosen to minimize hospitalization times and severe courses. In this single-center retrospective analysis, safety and efficacy of cyclophosphamide plus etoposide (CE) and growth-factor support (n = 33) was compared to cyclophosphamide mono treatment and growth-factor support (n = 49) in 82 patients with multiple myeloma at first diagnosis. CE was superior to cyclophosphamide mono with a significantly higher number of collected CD34+ cells (15.46 x 10(6) CD34(+) cells/kg vs. 9.92 x 10(6) CD34(+) cells/kg), significantly faster engraftment of granulocytes after stem cell transplantation (day 10.5 vs. day 11.6), shorter duration of the inpatient stay (17.47 days vs. 19.16 days) and significantly less transfusions (8.82 % vs. 30.61 % patients receiving transfusions). The safety profile was comparable in both groups and in line with published data. We conclude that CE is a safe and highly effective mobilization protocol in patients with multiple myeloma at first diagnosis and appears to be superior to the commonly used cyclophosphamide mono regimen. Twit Text FOAVip Cyclophosphamide plus etoposide is a safe and effective mobilization regimen in patients with multiple myeloma ????Transfus Apher Sci http://www.kidney.de/pget.php?&tw=1&pmid=34175195 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34175195 #FOAvip English Wikipedia <ref>{{Cite pmid|34175195}}</ref> Cyclophosphamide plus etoposide is a safe and effective mobilization regimen in patients with multiple myeloma #MMPMID34175195 Heider M; Grass S; Dill V; Ramisch S; Winter C; Verbeek M; Gotze KS; Bassermann F; Jilg S Transfus Apher Sci 2021[Oct]; 60 (5): 103197 PMID34175195show ga High-dose chemotherapy followed by autologous stem cell transplantation is a major component in the treatment of patients with multiple myeloma. As a prerequisite, the successful collection of a sufficient number of viable peripheral blood hematopoietic CD34+ cells is critical. A common standard protocol for mobilization is currently not defined and critically discussed especially in German-speaking Europe. In times of the Covid-19 pandemic, safe and effective strategies have to be chosen to minimize hospitalization times and severe courses. In this single-center retrospective analysis, safety and efficacy of cyclophosphamide plus etoposide (CE) and growth-factor support (n = 33) was compared to cyclophosphamide mono treatment and growth-factor support (n = 49) in 82 patients with multiple myeloma at first diagnosis. CE was superior to cyclophosphamide mono with a significantly higher number of collected CD34+ cells (15.46 x 10(6) CD34(+) cells/kg vs. 9.92 x 10(6) CD34(+) cells/kg), significantly faster engraftment of granulocytes after stem cell transplantation (day 10.5 vs. day 11.6), shorter duration of the inpatient stay (17.47 days vs. 19.16 days) and significantly less transfusions (8.82 % vs. 30.61 % patients receiving transfusions). The safety profile was comparable in both groups and in line with published data. We conclude that CE is a safe and highly effective mobilization protocol in patients with multiple myeloma at first diagnosis and appears to be superior to the commonly used cyclophosphamide mono regimen. |Aged[MESH] |Antineoplastic Combined Chemotherapy Protocols/*pharmacology/therapeutic use[MESH] |COVID-19[MESH] |Cyclophosphamide/administration & dosage/adverse effects/*pharmacology[MESH] |Etoposide/administration & dosage/adverse effects/*pharmacology[MESH] |Female[MESH] |Granulocyte Colony-Stimulating Factor/pharmacology[MESH] |Hematopoietic Stem Cell Mobilization/*methods[MESH] |Hematopoietic Stem Cells/*drug effects[MESH] |Humans[MESH] |Male[MESH] |Melphalan/administration & dosage[MESH] |Middle Aged[MESH] |Multiple Myeloma/blood/*therapy[MESH] |Myeloma Proteins/analysis[MESH] |Pandemics[MESH] |Peripheral Blood Stem Cell Transplantation/*methods[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Cyclophosphamide plus etoposide is a safe and effective mobilization r(epmc).pdf DeepDyve Pubget Overpricing