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10.1002/advs.202100693 http://scihub22266oqcxt.onion/10.1002/advs.202100693 34189857!8373117!34189857     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34189857.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Sci+(Weinh) 2021 ; 8 (16): e2100693 Nephropedia Template TP {{tp|p=34189857|t=2021. Influenza Virus Infects and Depletes Activated Adaptive Immune Responders |pdf=|usr=}}{{34189857}} gab.com Text Influenza Virus Infects and Depletes Activated Adaptive Immune Responders JO: Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=34189857 #FOAvip Influenza infections cause several million cases of severe respiratory illness, hospitalizations, and hundreds of thousands of deaths globally. Secondary infections are a leading cause of influenza's high morbidity and mortality, and significantly factored into the severity of the 1918, 1968, and 2009 pandemics. Furthermore, there is an increased incidence of other respiratory infections even in vaccinated individuals during influenza season. Putative mechanisms responsible for vaccine failures against influenza as well as other respiratory infections during influenza season are investigated. Peripheral blood mononuclear cells (PBMCs) are used from influenza vaccinated individuals to assess antigen-specific responses to influenza, measles, and varicella. The observations made in humans to a mouse model to unravel the mechanism is confirmed and extended. Infection with influenza virus suppresses an ongoing adaptive response to vaccination against influenza as well as other respiratory pathogens, i.e., Adenovirus and Streptococcus pneumoniae by preferentially infecting and killing activated lymphocytes which express elevated levels of sialic acid receptors. These findings propose a new mechanism for the high incidence of secondary respiratory infections due to bacteria and other viruses as well as vaccine failures to influenza and other respiratory pathogens even in immune individuals due to influenza viral infections. Twit Text FOAVip Influenza Virus Infects and Depletes Activated Adaptive Immune Responders ????Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=34189857 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34189857 #FOAvip English Wikipedia <ref>{{Cite pmid|34189857}}</ref> Influenza Virus Infects and Depletes Activated Adaptive Immune Responders #MMPMID34189857 Bohannon CD; Ende Z; Cao W; Mboko WP; Ranjan P; Kumar A; Mishina M; Amoah S; Gangappa S; Mittal SK; Lovell JF; Garcia-Sastre A; Pfeifer BA; Davidson BA; Knight P; Sambhara S Adv Sci (Weinh) 2021[Aug]; 8 (16): e2100693 PMID34189857show ga Influenza infections cause several million cases of severe respiratory illness, hospitalizations, and hundreds of thousands of deaths globally. Secondary infections are a leading cause of influenza's high morbidity and mortality, and significantly factored into the severity of the 1918, 1968, and 2009 pandemics. Furthermore, there is an increased incidence of other respiratory infections even in vaccinated individuals during influenza season. Putative mechanisms responsible for vaccine failures against influenza as well as other respiratory infections during influenza season are investigated. Peripheral blood mononuclear cells (PBMCs) are used from influenza vaccinated individuals to assess antigen-specific responses to influenza, measles, and varicella. The observations made in humans to a mouse model to unravel the mechanism is confirmed and extended. Infection with influenza virus suppresses an ongoing adaptive response to vaccination against influenza as well as other respiratory pathogens, i.e., Adenovirus and Streptococcus pneumoniae by preferentially infecting and killing activated lymphocytes which express elevated levels of sialic acid receptors. These findings propose a new mechanism for the high incidence of secondary respiratory infections due to bacteria and other viruses as well as vaccine failures to influenza and other respiratory pathogens even in immune individuals due to influenza viral infections. |Adaptive Immunity/*immunology[MESH] |Animals[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Humans[MESH] |Influenza, Human/*immunology[MESH] |Mice[MESH]Influenza Virus Infects and Depletes Activated Adaptive Immune Respond(epmc).pdf DeepDyve Pubget Overpricing