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10.1093/jalm/jfab081

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suck abstract from ncbi


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pmid34191020      J+Appl+Lab+Med 2021 ; 6 (6): 1484-1491
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  • Evaluation of Inappropriate COVID-19 RT-PCR Test Utilization at an Academic Medical Center #MMPMID34191020
  • Hardy NL; Luethy PM
  • J Appl Lab Med 2021[Nov]; 6 (6): 1484-1491 PMID34191020show ga
  • BACKGROUND: An evolving COVID-19 testing landscape and issues with test supply allocation, especially in the current pandemic, has made it challenging for ordering providers. We audited orders of the Xpert(R) Xpress SARS-CoV-2 PCR with reverse transcription (RT-PCR) platform-the fastest of several other testing modalities available-to illuminate these challenges utilizing a multidisciplinary laboratory professional team consisting of a pathology resident and microbiology laboratory director. METHODS: Retrospective review of the first 5 hundred Xpert Xpress SARS-CoV-2 RT-PCR test orders from a 2-week period to determine test appropriateness based on the following indications: emergency surgery, emergent obstetric procedures, initial behavioral health admission, and later including discharge to skilled care facilities and pediatric admissions. Our hypothesis was that a significant proportion of orders for this testing platform were inappropriate. RESULTS: On review, a significant proportion of orders were incorrect, with 69.8% (n = 349, P < 0.0001) not meeting indications for rapid testing. Of all orders, 249 designated as emergency surgery were inappropriate, with 49.0% of those orders never proceeding with any surgical intervention; most of these were trauma related (64.6% were orders associated with a trauma unit). CONCLUSIONS: Significant, pervasive inappropriate ordering practices were identified at this center. A laboratory professional team can be key to identifying problems in testing and play a significant role in combating inappropriate test utilization.
  • |*COVID-19[MESH]
  • |Academic Medical Centers[MESH]
  • |COVID-19 Testing[MESH]
  • |Child[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Pregnancy[MESH]
  • |Retrospective Studies[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]


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