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10.1080/19466315.2020.1779122

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34191971!8011486!34191971
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suck abstract from ncbi


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pmid34191971      Stat+Biopharm+Res 2020 ; 12 (4): 399-411
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  • Statistical Issues and Recommendations for Clinical Trials Conducted During the COVID-19 Pandemic #MMPMID34191971
  • Meyer RD; Ratitch B; Wolbers M; Marchenko O; Quan H; Li D; Fletcher C; Li X; Wright D; Shentu Y; Englert S; Shen W; Dey J; Liu T; Zhou M; Bohidar N; Zhao PL; Hale M
  • Stat Biopharm Res 2020[Jul]; 12 (4): 399-411 PMID34191971show ga
  • Abstract-The COVID-19 pandemic has had and continues to have major impacts on planned and ongoing clinical trials. Its effects on trial data create multiple potential statistical issues. The scale of impact is unprecedented, but when viewed individually, many of the issues are well defined and feasible to address. A number of strategies and recommendations are put forward to assess and address issues related to estimands, missing data, validity and modifications of statistical analysis methods, need for additional analyses, ability to meet objectives and overall trial interpretability.
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