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Nutrients 2021 ; 13 (7): � Nephropedia Template TP
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Association between Hyperglycemia at Hospital Presentation and Hospital Outcomes in COVID-19 Patients with and without Type 2 Diabetes: A Retrospective Cohort Study of Hospitalized Inner-City COVID-19 Patients #MMPMID34206813Charoenngam N; Alexanian SM; Apovian CM; Holick MFNutrients 2021[Jun]; 13 (7): � PMID34206813show ga
This study aimed to determine the relationships among hyperglycemia (HG), the presence of type 2 diabetes (T2D), and the outcomes of COVID-19. Demographic data, blood glucose levels (BG) measured on admission, and hospital outcomes of COVID-19 patients hospitalized at Boston University Medical Center from 1 March to 4 August 2020 were extracted from the hospital database. HG was defined as BG > 200 mg/dL. Patients with type 1 diabetes or BG < 70 mg/dL were excluded. A total of 458 patients with T2D and 976 patients without T2D were included in the study. The mean +/- SD age was 56 +/- 17 years and 642 (45%) were female. HG occurred in 193 (42%) and 42 (4%) of patients with and without T2D, respectively. Overall, the in-hospital mortality rate was 9%. Among patients without T2D, HG was statistically significantly associated with mortality, ICU admission, intubation, acute kidney injury, and severe sepsis/septic shock, after adjusting for potential confounders (p < 0.05). However, only ICU admission and acute kidney injury were associated with HG among patients with T2D (p < 0.05). Among the 235 patients with HG, the presence of T2D was associated with decreased odds of mortality, ICU admission, intubation, and severe sepsis/septic shock, after adjusting for potential confounders, including BG (p < 0.05). In conclusion, HG in the subset of patients without T2D could be a strong indicator of high inflammatory burden, leading to a higher risk of severe COVID-19.|Acute Kidney Injury/epidemiology[MESH]|Adult[MESH]|Aged[MESH]|Blood Glucose[MESH]|Boston/epidemiology[MESH]|COVID-19/*epidemiology/mortality[MESH]|Cohort Studies[MESH]|Diabetes Mellitus, Type 2/*epidemiology[MESH]|Female[MESH]|Hospital Mortality[MESH]|Hospitalization/*statistics & numerical data[MESH]|Humans[MESH]|Hyperglycemia/*epidemiology[MESH]|Intensive Care Units/statistics & numerical data[MESH]|Intubation/statistics & numerical data[MESH]|Male[MESH]|Middle Aged[MESH]|Retrospective Studies[MESH]|SARS-CoV-2[MESH]|Sepsis/epidemiology[MESH]|Severity of Illness Index[MESH]
  
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