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10.1186/s40001-021-00563-1 http://scihub22266oqcxt.onion/10.1186/s40001-021-00563-1 34344463!8329616!34344463     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34344463&cmd=llinks): Failed to open stream: HTTP request failed! 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Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature |pdf=|usr=}}{{34344463}} gab.com Text Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature JO: Eur J Med Res http://www.kidney.de/pget.php?&tw=1&pmid=34344463 #FOAvip The COVID-19 pandemic has markedly impacted on cultural, political, and economic structures all over the world. Several aspects of its pathogenesis and related clinical consequences have not yet been elucidated. Infection rates, as well morbidity and mortality differed within countries. It is intriguing for scientists to understand how patient genetics may influence the outcome of the condition, to clarify which aspects could be related the clinical variability of SARS-CoV-2 disease. We reviewed the studies exploring the role of human leukocyte antigens (HLA) genotypes on individual responses to SARS-CoV-2 infection and/or progression, discussing also the contribution of the immunological patterns MHC-related. In March 2021, the main online databases were accessed. All the articles that investigated the possible association between the HLA genotypes and related polymorphisms with susceptibility, severity and progression of COVID-19 were considered. Although both genetic and environmental factors are certainly expected to influence the susceptibility to or protection of individuals, the HLA and related polymorphisms can influence susceptibility, progression and severity of SARS-CoV-2 infection. The crucial role played by HLA molecules in the immune response, especially through pathogen-derived peptide presentation, and the huge molecular variability of HLA alleles in the human populations could be responsible for the different rates of infection and the different patients following COVID-19 infection. Twit Text FOAVip Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature ????Eur J Med Res http://www.kidney.de/pget.php?&tw=1&pmid=34344463 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34344463 #FOAvip English Wikipedia <ref>{{Cite pmid|34344463}}</ref> Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature #MMPMID34344463 Migliorini F; Torsiello E; Spiezia F; Oliva F; Tingart M; Maffulli N Eur J Med Res 2021[Aug]; 26 (1): 84 PMID34344463show ga The COVID-19 pandemic has markedly impacted on cultural, political, and economic structures all over the world. Several aspects of its pathogenesis and related clinical consequences have not yet been elucidated. Infection rates, as well morbidity and mortality differed within countries. It is intriguing for scientists to understand how patient genetics may influence the outcome of the condition, to clarify which aspects could be related the clinical variability of SARS-CoV-2 disease. We reviewed the studies exploring the role of human leukocyte antigens (HLA) genotypes on individual responses to SARS-CoV-2 infection and/or progression, discussing also the contribution of the immunological patterns MHC-related. In March 2021, the main online databases were accessed. All the articles that investigated the possible association between the HLA genotypes and related polymorphisms with susceptibility, severity and progression of COVID-19 were considered. Although both genetic and environmental factors are certainly expected to influence the susceptibility to or protection of individuals, the HLA and related polymorphisms can influence susceptibility, progression and severity of SARS-CoV-2 infection. The crucial role played by HLA molecules in the immune response, especially through pathogen-derived peptide presentation, and the huge molecular variability of HLA alleles in the human populations could be responsible for the different rates of infection and the different patients following COVID-19 infection. |*Genetic Predisposition to Disease[MESH] |*SARS-CoV-2[MESH] |Alleles[MESH] |COVID-19/etiology/*genetics/immunology[MESH] |Disease Progression[MESH] |Genotype[MESH] |HLA Antigens/*genetics[MESH] |Humans[MESH]Association between HLA genotypes and COVID-19 susceptibility, severit(epmc).pdf DeepDyve Pubget Overpricing