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10.1111/dth.15088

http://scihub22266oqcxt.onion/10.1111/dth.15088
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suck abstract from ncbi


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pmid34355846      Dermatol+Ther 2021 ; 34 (5): e15088
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  • Switching infliximab in psoriatic patients during COVID-19 pandemics: A real-life retrospective study comparing intra-versus interclass switching strategies #MMPMID34355846
  • Conti A; Damiani G; Ruggeri R; Odorici G; Farnetani F; Pigatto PDM; Pellacani G
  • Dermatol Ther 2021[Sep]; 34 (5): e15088 PMID34355846show ga
  • During this pandemic, dermatological infusion centers were partially unavailable, suspended or even reconverted to guest COVID-19 patients, consequently infliximab (IFX) infusions became challenging for their both logistic arrangement and also for patients' COVID-19 phobia. This 48 weeks follow-up retrospective observational study included 37 PsO patients that underwent IFX SB2 during pandemic in two primary dermatological referral centers. In 23 (62.1%) we had to switch from IFX to other biologics, not motivated by adverse reactions, contraindication or even loss of response but only to pandemic related conditions. Nine patients underwent interclass switching and 15 underwent intraclass switching; interestingly 2 patients that underwent adalimumab SB-5 switched back to IFX. Interclass switching was privileged in elder patients and smokers. All patients at week 48 achieved PASI 100. Intra- and interclass switchings are both safe and effective strategies in psoriatic patients with COVID-19 phobia and/or difficulties to undergo infliximab infusions.
  • |*COVID-19[MESH]
  • |*Pandemics[MESH]
  • |Adalimumab[MESH]
  • |Aged[MESH]
  • |Humans[MESH]
  • |Infliximab/adverse effects[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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