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10.1055/a-1562-2521 http://scihub22266oqcxt.onion/10.1055/a-1562-2521 34470068!�!34470068 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34470068&cmd=llinks): Failed to open stream: HTTP request failed! 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COVID-19: Risks, Complications, and Monitoring in Patients on Clozapine |pdf=|usr=}}{{34470068}} gab.com Text COVID-19: Risks, Complications, and Monitoring in Patients on Clozapine JO: Pharmacopsychiatry http://www.kidney.de/pget.php?&tw=1&pmid=34470068 #FOAvip The Dutch Clozapine Collaboration Group is frequently asked for advice about the management of clozapine-treated patients when infected with or vaccinated against SARS-CoV-2. We provide state of the art information about the risks of SARS-CoV-2 infection for patients on clozapine and we give advice on measures to be taken, especially in regard to the monitoring of clozapine plasma levels, WBC count and differentiation during COVID-19 and after vaccination. We present an overview of relevant editorials, observational studies, and case studies, in which COVID-19 was reported in patients on clozapine. Patients using clozapine may have a higher risk of infection than patients with schizophrenia spectrum disorders (SSD) using other antipsychotics. SARS-CoV-2 infection can result in a dangerous increase of clozapine plasma levels, and granulocytopenia and lymphocytopenia (generally mild and short-term) may also occur, usually not as a result of clozapine treatment. Clozapine intoxication, pneumonia and delirium are the main complications of COVID-19 in patients on clozapine. In order to prevent clozapine intoxication, reduction of the original dose by half is generally recommended in clozapine users who contract COVID-19. When a cytokine storm is suspected in an advanced stage of COVID-19, reduction by three quarters seems more appropriate. If COVID-19 patients on clozapine develop granulocytopenia, SARS-CoV-2, rather than clozapine, should be considered as the cause. Schizophrenia patients in general and clozapine users in particular belong to a high-risk group that warrants early vaccination on a medical indication. Twit Text FOAVip COVID-19: Risks, Complications, and Monitoring in Patients on Clozapine ????Pharmacopsychiatry http://www.kidney.de/pget.php?&tw=1&pmid=34470068 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34470068 #FOAvip English Wikipedia <ref>{{Cite pmid|34470068}}</ref> COVID-19: Risks, Complications, and Monitoring in Patients on Clozapine #MMPMID34470068 Veerman SRT; Bogers JPAM; Cohen D; Schulte PFJ Pharmacopsychiatry 2022[Jan]; 55 (1): 48-56 PMID34470068show ga The Dutch Clozapine Collaboration Group is frequently asked for advice about the management of clozapine-treated patients when infected with or vaccinated against SARS-CoV-2. We provide state of the art information about the risks of SARS-CoV-2 infection for patients on clozapine and we give advice on measures to be taken, especially in regard to the monitoring of clozapine plasma levels, WBC count and differentiation during COVID-19 and after vaccination. We present an overview of relevant editorials, observational studies, and case studies, in which COVID-19 was reported in patients on clozapine. Patients using clozapine may have a higher risk of infection than patients with schizophrenia spectrum disorders (SSD) using other antipsychotics. SARS-CoV-2 infection can result in a dangerous increase of clozapine plasma levels, and granulocytopenia and lymphocytopenia (generally mild and short-term) may also occur, usually not as a result of clozapine treatment. Clozapine intoxication, pneumonia and delirium are the main complications of COVID-19 in patients on clozapine. In order to prevent clozapine intoxication, reduction of the original dose by half is generally recommended in clozapine users who contract COVID-19. When a cytokine storm is suspected in an advanced stage of COVID-19, reduction by three quarters seems more appropriate. If COVID-19 patients on clozapine develop granulocytopenia, SARS-CoV-2, rather than clozapine, should be considered as the cause. Schizophrenia patients in general and clozapine users in particular belong to a high-risk group that warrants early vaccination on a medical indication. |*Antipsychotic Agents/adverse effects[MESH] |*COVID-19[MESH] |*Clozapine/adverse effects[MESH] |*Schizophrenia/drug therapy[MESH] |Humans[MESH]COVID-19: Risks, Complications, and Monitoring in Patients on Clozapin(epmc).pdf DeepDyve Pubget Overpricing