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Early insight into antibody-dependent enhancement after SARS-CoV-2 mRNA vaccination #MMPMID34543154
Hasan A; Al-Mulla MR; Abubaker J; Al-Mulla F
Hum Vaccin Immunother 2021[Nov]; 17 (11): 4121-4125 PMID34543154show ga
Current vaccines, which induce a B-cell-mediated antibody response against the spike protein of SARS-CoV-2, have markedly reduced infection rates. However, the emergence of new variants as a result of SARS-CoV-2 evolution requires the development of novel vaccines that are T-cell-based and that target mutant-specific spike proteins along with ORF1ab or nucleocapsid protein. This approach is more accommodative in inducing highly neutralizing antibodies, without the risk of antibody-dependent enhancement, as well as memory CD8(+)T-cell immunity.