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10.1007/s12011-021-03048-8 http://scihub22266oqcxt.onion/10.1007/s12011-021-03048-8 34825316!8614629!34825316     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34825316&cmd=llinks): Failed to open stream: HTTP request failed! 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Iron Chelator or Iron Supplement Consumption in COVID-19? The Role of Iron with Severity Infection |pdf=|usr=}}{{34825316}} gab.com Text Iron Chelator or Iron Supplement Consumption in COVID-19 The Role of Iron with Severity Infection JO: Biol Trace Elem Res http://www.kidney.de/pget.php?&tw=1&pmid=34825316 #FOAvip Iron is a trace element that is used to replicate the virus and has a role in the vital functions of the body and the host's innate immune system. The mechanism of iron in COVID-19 severity is still not well understood. The aim of this study was to evaluate the association of the iron with COVID-19 severity. A case-control study was performed on 147 patients with a positive PCR test result and 39 normal individuals admitted to the Persian Gulf Martyrs Hospital in Bushehr, Iran. The iron profiles and related tests were measured along with hematological analytes. Hemoglobin (Hb), Fe, and saturated transferrin decreased in all the groups compared to the controls, but ferritin increased in the patient groups. After adjusting for age and sex, we found that increased ferritin levels augmented the odds ratio (OR) of the disease in the moderate (OR = 2.95, P = 0.007), severe (OR = 6.1, P < 0.001), and critical groups (OR = 8.34, P < 0.001). The decreased levels of Fe reduced the OR of the disease in the mild (OR = 0.96, P < 0.001), moderate (OR = 0.96, P < 0.001), severe (OR = 0.95, P < 0.001), and critical (OR = 0.98, P = 0.001) groups. Fe (AUC = 85.95, cutoff < 75.5 microg/dL, P < 0.001) and ferritin (AUC = 84.45, cutoff > 157.5 ng/dL, P < 0.001) have higher AUC for disease prognosis, but only ferritin (AUC = 74.89, cutoff > 261.5 ng/dL, P < 0.001) has higher AUC for disease severity assays. It could be concluded that the use of iron chelators to reduce iron intake can be considered a therapeutic goal. In addition, measuring Fe and ferritin is beneficial for the diagnosis of the disease and determining its severity. Twit Text FOAVip Iron Chelator or Iron Supplement Consumption in COVID-19 The Role of Iron with Severity Infection ????Biol Trace Elem Res http://www.kidney.de/pget.php?&tw=1&pmid=34825316 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34825316 #FOAvip English Wikipedia <ref>{{Cite pmid|34825316}}</ref> Iron Chelator or Iron Supplement Consumption in COVID-19? The Role of Iron with Severity Infection #MMPMID34825316 Bastin A; Shiri H; Zanganeh S; Fooladi S; Momeni Moghaddam MA; Mehrabani M; Nematollahi MH Biol Trace Elem Res 2022[Nov]; 200 (11): 4571-4581 PMID34825316show ga Iron is a trace element that is used to replicate the virus and has a role in the vital functions of the body and the host's innate immune system. The mechanism of iron in COVID-19 severity is still not well understood. The aim of this study was to evaluate the association of the iron with COVID-19 severity. A case-control study was performed on 147 patients with a positive PCR test result and 39 normal individuals admitted to the Persian Gulf Martyrs Hospital in Bushehr, Iran. The iron profiles and related tests were measured along with hematological analytes. Hemoglobin (Hb), Fe, and saturated transferrin decreased in all the groups compared to the controls, but ferritin increased in the patient groups. After adjusting for age and sex, we found that increased ferritin levels augmented the odds ratio (OR) of the disease in the moderate (OR = 2.95, P = 0.007), severe (OR = 6.1, P < 0.001), and critical groups (OR = 8.34, P < 0.001). The decreased levels of Fe reduced the OR of the disease in the mild (OR = 0.96, P < 0.001), moderate (OR = 0.96, P < 0.001), severe (OR = 0.95, P < 0.001), and critical (OR = 0.98, P = 0.001) groups. Fe (AUC = 85.95, cutoff < 75.5 microg/dL, P < 0.001) and ferritin (AUC = 84.45, cutoff > 157.5 ng/dL, P < 0.001) have higher AUC for disease prognosis, but only ferritin (AUC = 74.89, cutoff > 261.5 ng/dL, P < 0.001) has higher AUC for disease severity assays. It could be concluded that the use of iron chelators to reduce iron intake can be considered a therapeutic goal. In addition, measuring Fe and ferritin is beneficial for the diagnosis of the disease and determining its severity. |*COVID-19[MESH] |*Trace Elements[MESH] |Case-Control Studies[MESH] |Ferritins[MESH] |Hemoglobins/metabolism[MESH] |Humans[MESH] |Iron Chelating Agents/therapeutic use[MESH] |Iron/metabolism[MESH]Iron Chelator or Iron Supplement Consumption in COVID-19? The Role of (epmc).pdf DeepDyve Pubget Overpricing