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10.1101/2021.11.23.21266767 http://scihub22266oqcxt.onion/10.1101/2021.11.23.21266767 34845458!8629202!34845458     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34845458.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       medRxiv 2021 ; ä (ä): ä Nephropedia Template TP {{tp|p=34845458|t=2021. An immune correlate of SARS-CoV-2 infection and severity of reinfections |pdf=|usr=}}{{34845458}} gab.com Text An immune correlate of SARS-CoV-2 infection and severity of reinfections JO: medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=34845458 #FOAvip BACKGROUND: An immune correlate of protection from SARS-CoV-2 infection is urgently needed. METHODS: We used an ongoing household cohort with an embedded transmission study that closely monitors participants regardless of symptom status. Real-time reverse-transcription polymerase chain reaction (RT-PCR) and Enzyme-linked immunosorbent assays (ELISAs) were used to measure infections and seropositivity. Sequencing was performed to determine circulating strains of SARS-CoV-2. We investigated the protection associated with seropositivity resulting from prior infection, the anti-spike antibody titers needed for protection, and we compared the severity of first and second infections. RESULTS: In March 2021, 62.3% of the cohort was seropositive. After March 2021, gamma and delta variants predominated. Seropositivity was associated with 69.2% protection from any infection (95% CI: 60.7%-75.9%), with higher protection against moderate or severe infection (79.4%, 95% CI: 64.9%-87.9%). Anti-spike titers of 327 and 2,551 were associated with 50% and 80% protection from any infection; titers of 284 and 656 were sufficient for protection against moderate or severe disease. Second infections were less severe than first infections (Relative Risk (RR) of moderated or severe disease: 0.6, 95% CI: 0.38-0.98; RR of subclinical disease:1.9, 95% CI: 1.33-2.73). CONCLUSIONS: Prior infection-induced immunity is protective against infection when predominantly gamma and delta SARS-CoV-2 circulated. The protective antibody titers presented may be useful for vaccine policy and control measures. While second infections were somewhat less severe, they were not as mild as ideal. A strategy involving vaccination will be needed to ease the burden of the SARS-CoV-2 pandemic. Twit Text FOAVip An immune correlate of SARS-CoV-2 infection and severity of reinfections ????medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=34845458 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34845458 #FOAvip English Wikipedia <ref>{{Cite pmid|34845458}}</ref> An immune correlate of SARS-CoV-2 infection and severity of reinfections #MMPMID34845458 Maier HE; Balmaseda A; Ojeda S; Cerpas C; Sanchez N; Plazaola M; van Bakel H; Kubale J; Lopez R; Saborio S; Barilla C; Harris E; Kuan G; Gordon A medRxiv 2021[Nov]; ä (ä): ä PMID34845458show ga BACKGROUND: An immune correlate of protection from SARS-CoV-2 infection is urgently needed. METHODS: We used an ongoing household cohort with an embedded transmission study that closely monitors participants regardless of symptom status. Real-time reverse-transcription polymerase chain reaction (RT-PCR) and Enzyme-linked immunosorbent assays (ELISAs) were used to measure infections and seropositivity. Sequencing was performed to determine circulating strains of SARS-CoV-2. We investigated the protection associated with seropositivity resulting from prior infection, the anti-spike antibody titers needed for protection, and we compared the severity of first and second infections. RESULTS: In March 2021, 62.3% of the cohort was seropositive. After March 2021, gamma and delta variants predominated. Seropositivity was associated with 69.2% protection from any infection (95% CI: 60.7%-75.9%), with higher protection against moderate or severe infection (79.4%, 95% CI: 64.9%-87.9%). Anti-spike titers of 327 and 2,551 were associated with 50% and 80% protection from any infection; titers of 284 and 656 were sufficient for protection against moderate or severe disease. Second infections were less severe than first infections (Relative Risk (RR) of moderated or severe disease: 0.6, 95% CI: 0.38-0.98; RR of subclinical disease:1.9, 95% CI: 1.33-2.73). CONCLUSIONS: Prior infection-induced immunity is protective against infection when predominantly gamma and delta SARS-CoV-2 circulated. The protective antibody titers presented may be useful for vaccine policy and control measures. While second infections were somewhat less severe, they were not as mild as ideal. A strategy involving vaccination will be needed to ease the burden of the SARS-CoV-2 pandemic. äAn immune correlate of SARS-CoV-2 infection and severity of reinfectio(epmc).pdf DeepDyve Pubget Overpricing