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10.1007/s00011-021-01525-3 http://scihub22266oqcxt.onion/10.1007/s00011-021-01525-3 34850243!8631699!34850243     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34850243&cmd=llinks): Failed to open stream: HTTP request failed! 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Severity of SARS-CoV-2 infection is linked to double-negative (CD27(-) IgD(-)) B cell subset numbers |pdf=|usr=}}{{34850243}} gab.com Text Severity of SARS-CoV-2 infection is linked to double-negative (CD27(-) IgD(-)) B cell subset numbers JO: Inflamm Res http://www.kidney.de/pget.php?&tw=1&pmid=34850243 #FOAvip OBJECTIVES: The role of B cells in COVID-19, beyond the production of specific antibodies against SARS-CoV-2, is still not well understood. Here, we describe the novel landscape of circulating double-negative (DN) CD27(-) IgD(-) B cells in COVID-19 patients, representing a group of atypical and neglected subpopulations of this cell lineage. METHODS: Using multiparametric flow cytometry, we determined DN B cell subset amounts from 91 COVID-19 patients, correlated those with cytokines, clinical and laboratory parameters, and segregated them by principal components analysis. RESULTS: We detected significant increments in the DN2 and DN3 B cell subsets, while we found a relevant decrease in the DN1 B cell subpopulation, according to disease severity and patient outcomes. These DN cell numbers also appeared to correlate with pro- or anti-inflammatory signatures, respectively, and contributed to the segregation of the patients into disease severity groups. CONCLUSION: This study provides insights into DN B cell subsets' potential role in immune responses against SARS-CoV-2, particularly linked to the severity of COVID-19. Twit Text FOAVip Severity of SARS-CoV-2 infection is linked to double-negative (CD27(-) IgD(-)) B cell subset numbers ????Inflamm Res http://www.kidney.de/pget.php?&tw=1&pmid=34850243 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34850243 #FOAvip English Wikipedia <ref>{{Cite pmid|34850243}}</ref> Severity of SARS-CoV-2 infection is linked to double-negative (CD27(-) IgD(-)) B cell subset numbers #MMPMID34850243 Cervantes-Diaz R; Sosa-Hernandez VA; Torres-Ruiz J; Romero-Ramirez S; Canez-Hernandez M; Perez-Fragoso A; Paez-Franco JC; Meza-Sanchez DE; Pescador-Rojas M; Sosa-Hernandez VA; Gomez-Martin D; Maravillas-Montero JL Inflamm Res 2022[Jan]; 71 (1): 131-140 PMID34850243show ga OBJECTIVES: The role of B cells in COVID-19, beyond the production of specific antibodies against SARS-CoV-2, is still not well understood. Here, we describe the novel landscape of circulating double-negative (DN) CD27(-) IgD(-) B cells in COVID-19 patients, representing a group of atypical and neglected subpopulations of this cell lineage. METHODS: Using multiparametric flow cytometry, we determined DN B cell subset amounts from 91 COVID-19 patients, correlated those with cytokines, clinical and laboratory parameters, and segregated them by principal components analysis. RESULTS: We detected significant increments in the DN2 and DN3 B cell subsets, while we found a relevant decrease in the DN1 B cell subpopulation, according to disease severity and patient outcomes. These DN cell numbers also appeared to correlate with pro- or anti-inflammatory signatures, respectively, and contributed to the segregation of the patients into disease severity groups. CONCLUSION: This study provides insights into DN B cell subsets' potential role in immune responses against SARS-CoV-2, particularly linked to the severity of COVID-19. |*SARS-CoV-2[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |B-Lymphocytes/cytology[MESH] |COVID-19/*blood/diagnosis/*immunology/virology[MESH] |Cell Lineage[MESH] |Computational Biology[MESH] |Disease Progression[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin D/*blood[MESH] |Male[MESH] |Middle Aged[MESH] |Principal Component Analysis[MESH] |Prognosis[MESH] |Respiration, Artificial[MESH] |Severity of Illness Index[MESH] |Tumor Necrosis Factor Receptor Superfamily, Member 7/*blood[MESH]Severity of SARS-CoV-2 infection is linked to double-negative (CD27(-)(epmc).pdf DeepDyve Pubget Overpricing