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10.1126/sciimmunol.abm5505 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abm5505 34995097!�!34995097 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34995097&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34995097.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Immunol 2022 ; 7 (67): eabm5505 Nephropedia Template TP {{tp|p=34995097|t=2022. Innate immunological pathways in COVID-19 pathogenesis |pdf=|usr=}}{{34995097}} gab.com Text Innate immunological pathways in COVID-19 pathogenesis JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34995097 #FOAvip Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound dysregulation of the innate immune system. This knowledge has emerged from the large body of single-cell omics studies of patients with COVID-19, which have provided one of the most detailed cellular atlases of a human disease ever. However, we are only beginning to understand the innate immunological pathways that govern host defense and immunopathology in COVID-19. In this review, we discuss the emerging understanding of how SARS-CoV-2 and host-derived molecules activate specific pattern recognition receptors to elicit protective interferon responses and pathological cytokine responses, with particular focus on acute infection of the lung and lung pathophysiology in critical COVID-19. In addition, we discuss how these pathways are modulated by virus-host interactions and host stress-sensing pathways. In-depth understanding of the disease mechanisms will likely uncover specific molecular targets for the treatment of COVID-19 and other emerging viral infections. In addition, it will reveal the fine balance between beneficial protective versus pathological disease causing immune responses. Twit Text FOAVip Innate immunological pathways in COVID-19 pathogenesis ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34995097 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34995097 #FOAvip English Wikipedia <ref>{{Cite pmid|34995097}}</ref> Innate immunological pathways in COVID-19 pathogenesis #MMPMID34995097 Paludan SR; Mogensen TH Sci Immunol 2022[Jan]; 7 (67): eabm5505 PMID34995097show ga Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound dysregulation of the innate immune system. This knowledge has emerged from the large body of single-cell omics studies of patients with COVID-19, which have provided one of the most detailed cellular atlases of a human disease ever. However, we are only beginning to understand the innate immunological pathways that govern host defense and immunopathology in COVID-19. In this review, we discuss the emerging understanding of how SARS-CoV-2 and host-derived molecules activate specific pattern recognition receptors to elicit protective interferon responses and pathological cytokine responses, with particular focus on acute infection of the lung and lung pathophysiology in critical COVID-19. In addition, we discuss how these pathways are modulated by virus-host interactions and host stress-sensing pathways. In-depth understanding of the disease mechanisms will likely uncover specific molecular targets for the treatment of COVID-19 and other emerging viral infections. In addition, it will reveal the fine balance between beneficial protective versus pathological disease causing immune responses. |*COVID-19/immunology/pathology/physiopathology[MESH] |*Immunity, Innate[MESH] |*Lung/immunology/pathology/physiopathology[MESH] |Humans[MESH] |SARS-CoV-2/*immunology[MESH]Innate immunological pathways in COVID-19 pathogenesis (epmc).pdf DeepDyve Pubget Overpricing