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10.1186/s12879-022-07064-4 http://scihub22266oqcxt.onion/10.1186/s12879-022-07064-4 35065613!8783581!35065613     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35065613&cmd=llinks): Failed to open stream: HTTP request failed! 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Low incidence of COVID-19 case severity and mortality in Africa; Could malaria co-infection provide the missing link?|pdf=|usr=}}{{35065613}} gab.com Text Low incidence of COVID-19 case severity and mortality in Africa; Could malaria co-infection provide the missing link JO: BMC Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=35065613 #FOAvip BACKGROUND: Despite reports of malaria and coronavirus diseases 2019 (COVID-19) co-infection, malaria-endemic regions have so far recorded fewer cases of COVID-19 and deaths from COVID-19, indicating a probable protection from the poor outcome of COVID-19 by malaria. On the contrary, other evidence suggests that malaria might contribute to the death caused by COVID-19. Hence, this paper reviewed existing evidence hypothesizing poor outcome or protection of COVID-19 patients when co-infected with malaria. METHODS: PRISMA guidelines for systematic review were employed in this study. Published articles from December 2019 to May 2021on COVID-19 and malaria co-infection and outcome were systematically searched in relevant and accessible databases following a pre-defined strategy. Studies involving human, in vivo animal studies, and in vitro studies were included. RESULTS: Twenty three (23) studies were included in the review out of the 3866 records identified in the selected scientific databases. Nine (9) papers reported on co-infection of COVID-19 and malaria. Five (5) papers provided information about synergism of malaria and COVID-19 poor prognosis, 2 papers reported on syndemic of COVID-19 and malaria intervention, and 7 studies indicated that malaria protects individuals from COVID-19. CONCLUSIONS: Low incidence of COVID-19 in malaria-endemic regions supports the hypothesis that COVID-19 poor prognosis is prevented by malaria. Although further studies are required to ascertain this hypothesis, cross-immunity and common immunodominant isotopes provide strong evidence to support this hypothesis. Also, increase in co-inhibitory receptors and atypical memory B cells indicate synergy between COVID-19 and malaria outcome, though, more studies are required to make a definite conclusion. Twit Text FOAVip Low incidence of COVID-19 case severity and mortality in Africa; Could malaria co-infection provide the missing link ????BMC Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=35065613 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35065613 #FOAvip English Wikipedia <ref>{{Cite pmid|35065613}}</ref> Low incidence of COVID-19 case severity and mortality in Africa; Could malaria co-infection provide the missing link? #MMPMID35065613 Osei SA; Biney RP; Anning AS; Nortey LN; Ghartey-Kwansah G BMC Infect Dis 2022[Jan]; 22 (1): 78 PMID35065613show ga BACKGROUND: Despite reports of malaria and coronavirus diseases 2019 (COVID-19) co-infection, malaria-endemic regions have so far recorded fewer cases of COVID-19 and deaths from COVID-19, indicating a probable protection from the poor outcome of COVID-19 by malaria. On the contrary, other evidence suggests that malaria might contribute to the death caused by COVID-19. Hence, this paper reviewed existing evidence hypothesizing poor outcome or protection of COVID-19 patients when co-infected with malaria. METHODS: PRISMA guidelines for systematic review were employed in this study. Published articles from December 2019 to May 2021on COVID-19 and malaria co-infection and outcome were systematically searched in relevant and accessible databases following a pre-defined strategy. Studies involving human, in vivo animal studies, and in vitro studies were included. RESULTS: Twenty three (23) studies were included in the review out of the 3866 records identified in the selected scientific databases. Nine (9) papers reported on co-infection of COVID-19 and malaria. Five (5) papers provided information about synergism of malaria and COVID-19 poor prognosis, 2 papers reported on syndemic of COVID-19 and malaria intervention, and 7 studies indicated that malaria protects individuals from COVID-19. CONCLUSIONS: Low incidence of COVID-19 in malaria-endemic regions supports the hypothesis that COVID-19 poor prognosis is prevented by malaria. Although further studies are required to ascertain this hypothesis, cross-immunity and common immunodominant isotopes provide strong evidence to support this hypothesis. Also, increase in co-inhibitory receptors and atypical memory B cells indicate synergy between COVID-19 and malaria outcome, though, more studies are required to make a definite conclusion. |*COVID-19[MESH] |*Coinfection/epidemiology[MESH] |*Malaria/complications/epidemiology[MESH] |Africa/epidemiology[MESH] |Animals[MESH] |Humans[MESH] |Incidence[MESH] |Memory B Cells[MESH]Low incidence of COVID-19 case severity and mortality in Africa; Could(epmc).pdf DeepDyve Pubget Overpricing