Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/bjh.18062 http://scihub22266oqcxt.onion/10.1111/bjh.18062 35076084!ä!35076084 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35076084.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Br+J+Haematol 2022 ; 197 (3): 283-292 Nephropedia Template TP {{tp|p=35076084|t=2022. Platelets modulate CD4(+) T-cell function in COVID-19 through a PD-L1 dependent mechanism |pdf=|usr=}}{{35076084}} gab.com Text Platelets modulate CD4(+) T-cell function in COVID-19 through a PD-L1 dependent mechanism JO: Br J Haematol http://www.kidney.de/pget.php?&tw=1&pmid=35076084 #FOAvip Severe COVID-19 is associated with a systemic inflammatory response and progressive CD4(+) T-cell lymphopenia and dysfunction. We evaluated whether platelets might contribute to CD4(+) T-cell dysfunction in COVID-19. We observed a high frequency of CD4(+) T cell-platelet aggregates in COVID-19 inpatients that inversely correlated with lymphocyte counts. Platelets from COVID-19 inpatients but not from healthy donors (HD) inhibited the upregulation of CD25 expression and tumour necrosis factor (TNF)-alpha production by CD4(+) T cells. In addition, interferon (IFN)-gamma production was increased by platelets from HD but not from COVID-19 inpatients. A high expression of PD-L1 was found in platelets from COVID-19 patients to be inversely correlated with IFN-gamma production by activated CD4(+) T cells cocultured with platelets. We also found that a PD-L1-blocking antibody significantly restored platelets' ability to stimulate IFN-gamma production by CD4(+) T cells. Our study suggests that platelets might contribute to disease progression in COVID-19 not only by promoting thrombotic and inflammatory events, but also by affecting CD4(+) T cells functionality. Twit Text FOAVip Platelets modulate CD4(+) T-cell function in COVID-19 through a PD-L1 dependent mechanism ????Br J Haematol http://www.kidney.de/pget.php?&tw=1&pmid=35076084 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35076084 #FOAvip English Wikipedia <ref>{{Cite pmid|35076084}}</ref> Platelets modulate CD4(+) T-cell function in COVID-19 through a PD-L1 dependent mechanism #MMPMID35076084 Paletta A; Di Diego Garcia F; Varese A; Erra Diaz F; Garcia J; Cisneros JC; Luduena G; Mazzitelli I; Pisarevsky A; Cabrerizo G; Lopez Malizia A; Rodriguez AG; Lista N; Longueira Y; Sabatte J; Geffner J; Remes Lenicov F; Ceballos A Br J Haematol 2022[May]; 197 (3): 283-292 PMID35076084show ga Severe COVID-19 is associated with a systemic inflammatory response and progressive CD4(+) T-cell lymphopenia and dysfunction. We evaluated whether platelets might contribute to CD4(+) T-cell dysfunction in COVID-19. We observed a high frequency of CD4(+) T cell-platelet aggregates in COVID-19 inpatients that inversely correlated with lymphocyte counts. Platelets from COVID-19 inpatients but not from healthy donors (HD) inhibited the upregulation of CD25 expression and tumour necrosis factor (TNF)-alpha production by CD4(+) T cells. In addition, interferon (IFN)-gamma production was increased by platelets from HD but not from COVID-19 inpatients. A high expression of PD-L1 was found in platelets from COVID-19 patients to be inversely correlated with IFN-gamma production by activated CD4(+) T cells cocultured with platelets. We also found that a PD-L1-blocking antibody significantly restored platelets' ability to stimulate IFN-gamma production by CD4(+) T cells. Our study suggests that platelets might contribute to disease progression in COVID-19 not only by promoting thrombotic and inflammatory events, but also by affecting CD4(+) T cells functionality. |*B7-H1 Antigen/metabolism[MESH] |*COVID-19[MESH] |Blood Platelets/metabolism[MESH] |CD4-Positive T-Lymphocytes[MESH] |Humans[MESH]Platelets modulate CD4(+) T-cell function in COVID-19 through a PD-L1 (epmc).pdf DeepDyve Pubget Overpricing