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10.1016/j.euroneuro.2022.01.007 http://scihub22266oqcxt.onion/10.1016/j.euroneuro.2022.01.007 35152033!8784620!35152033     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35152033&cmd=llinks): Failed to open stream: HTTP request failed! 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COVID-related hospitalization, intensive care treatment, and all-cause mortality in patients with psychosis and treated with clozapine |pdf=|usr=}}{{35152033}} gab.com Text COVID-related hospitalization, intensive care treatment, and all-cause mortality in patients with psychosis and treated with clozapine JO: Eur Neuropsychopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=35152033 #FOAvip Clozapine, an antipsychotic, is associated with increased susceptibility to infection with COVID-19, compared to other antipsychotics. Here, we investigate associations between clozapine treatment and increased risk of adverse outcomes of COVID-19, namely COVID-related hospitalisation, intensive care treatment, and death, amongst patients taking antipsychotics with schizophrenia-spectrum disorders. Using the clinical records of South London and Maudsley NHS Foundation Trust, we identified 157 individuals who had an ICD-10 diagnosis of schizophrenia-spectrum disorders, were taking antipsychotics (clozapine or other antipsychotics) at the time of COVID-19 pandemic in the UK and had a laboratory-confirmed COVID-19 infection. The following health outcomes were measured: COVID-related hospitalisation, COVID-related intensive care treatment and death. We tested associations between clozapine treatment and each outcome using logistic regression models, adjusting for gender, age, ethnicity, neighbourhood deprivation, obesity, smoking status, diabetes, asthma, bronchitis and hypertension using propensity scores. Of the 157 individuals who developed COVID-19 while on antipsychotics (clozapine or other antipsychotics), there were 28% COVID-related hospitalisations, 8% COVID-related intensive care treatments and 8% deaths of any cause during the 28 days follow-up period. amongst those taking clozapine, there were 25% COVID-related hospitalisations, 7% COVID-related intensive care treatments and 7% deaths. In both unadjusted and adjusted analyses, we found no significant association between clozapine and any of the outcomes. Thus, we found no evidence that patients with clozapine treatment at time of COVID-19 infection had increased risk of hospitalisation, intensive care treatment or death, compared to non-clozapine antipsychotic-treated patients. However, further research should be considered in larger samples to confirm this. Twit Text FOAVip COVID-related hospitalization, intensive care treatment, and all-cause mortality in patients with psychosis and treated with clozapine ????Eur Neuropsychopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=35152033 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35152033 #FOAvip English Wikipedia <ref>{{Cite pmid|35152033}}</ref> COVID-related hospitalization, intensive care treatment, and all-cause mortality in patients with psychosis and treated with clozapine #MMPMID35152033 Govind R; de Freitas DF; Pritchard M; Khondoker M; Teo JT; Stewart R; Hayes RD; MacCabe JH Eur Neuropsychopharmacol 2022[Mar]; 56 (ä): 92-99 PMID35152033show ga Clozapine, an antipsychotic, is associated with increased susceptibility to infection with COVID-19, compared to other antipsychotics. Here, we investigate associations between clozapine treatment and increased risk of adverse outcomes of COVID-19, namely COVID-related hospitalisation, intensive care treatment, and death, amongst patients taking antipsychotics with schizophrenia-spectrum disorders. Using the clinical records of South London and Maudsley NHS Foundation Trust, we identified 157 individuals who had an ICD-10 diagnosis of schizophrenia-spectrum disorders, were taking antipsychotics (clozapine or other antipsychotics) at the time of COVID-19 pandemic in the UK and had a laboratory-confirmed COVID-19 infection. The following health outcomes were measured: COVID-related hospitalisation, COVID-related intensive care treatment and death. We tested associations between clozapine treatment and each outcome using logistic regression models, adjusting for gender, age, ethnicity, neighbourhood deprivation, obesity, smoking status, diabetes, asthma, bronchitis and hypertension using propensity scores. Of the 157 individuals who developed COVID-19 while on antipsychotics (clozapine or other antipsychotics), there were 28% COVID-related hospitalisations, 8% COVID-related intensive care treatments and 8% deaths of any cause during the 28 days follow-up period. amongst those taking clozapine, there were 25% COVID-related hospitalisations, 7% COVID-related intensive care treatments and 7% deaths. In both unadjusted and adjusted analyses, we found no significant association between clozapine and any of the outcomes. Thus, we found no evidence that patients with clozapine treatment at time of COVID-19 infection had increased risk of hospitalisation, intensive care treatment or death, compared to non-clozapine antipsychotic-treated patients. However, further research should be considered in larger samples to confirm this. |*Antipsychotic Agents/adverse effects[MESH] |*COVID-19[MESH] |*Clozapine/adverse effects[MESH] |*Psychotic Disorders/drug therapy/epidemiology[MESH] |Critical Care[MESH] |Hospitalization[MESH] |Humans[MESH] |Pandemics[MESH]COVID-related hospitalization, intensive care treatment, and all-cause(epmc).pdf DeepDyve Pubget Overpricing