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The association between daily-diagnosed COVID-19 morbidity and short-term exposure to PM(1) is larger than associations with PM(2 5) and PM(10) #MMPMID35218713
Xiong J; Li J; Wu X; Wolfson JM; Lawrence J; Stern RA; Koutrakis P; Wei J; Huang S
Environ Res 2022[Jul]; 210 (ä): 113016 PMID35218713show ga
Exposure to particulate matter (PM) could increase both susceptibility to SARS-CoV-2 infection and severity of COVID-19 disease. Prior studies investigating associations between PM and COVID-19 morbidity have only considered PM(2.5) or PM(10), rather than PM(1). We investigated the associations between daily-diagnosed COVID-19 morbidity and average exposures to ambient PM(1) starting at 0 through 21 days before the day of diagnosis in 12 cities in China using a two-step analysis: a time-series quasi-Poisson analysis to analyze the associations in each city; and then a meta-analysis to estimate the overall association. Diagnosed morbidities and PM(1) data were obtained from National Health Commission in China and China Meteorological Administration, respectively. We found association between short-term exposures to ambient PM(1) with COVID-19 morbidity was significantly positive, and larger than the associations with PM(2.5) and PM(10). Percent increases in daily-diagnosed COVID-19 morbidity per IQR/10 PM(1) for different moving averages ranged from 1.50% (-1.20%, 4.30%) to 241% (95%CI: 80.7%, 545%), with largest values for exposure windows starting at 17 days before diagnosis. Our results indicate that smaller particles are more highly associated with COVID-19 morbidity, and most of the effects from PM(2.5) and PM(10) on COVID-19 may be primarily due to the PM(1). This study will be helpful for implementing measures and policies to control the spread of COVID-19.