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10.1002/eji.202149470 http://scihub22266oqcxt.onion/10.1002/eji.202149470 35416291!9087393!35416291     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35416291&cmd=llinks): Failed to open stream: HTTP request failed! 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Natural killer cell-mediated ADCC in SARS-CoV-2-infected individuals and vaccine recipients |pdf=|usr=}}{{35416291}} gab.com Text Natural killer cell-mediated ADCC in SARS-CoV-2-infected individuals and vaccine recipients JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35416291 #FOAvip COVID-19, caused by SARS-CoV-2, has emerged as a global pandemic. While immune responses of the adaptive immune system have been in the focus of research, the role of NK cells in COVID-19 remains less well understood. Here, we characterized NK cell-mediated SARS-CoV-2 antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 spike-1 (S1) and nucleocapsid (NC) protein. Serum samples from SARS-CoV-2 resolvers induced significant CD107a-expression by NK cells in response to S1 and NC, while serum samples from SARS-CoV-2-negative individuals did not. Furthermore, serum samples from individuals that received the BNT162b2 vaccine induced strong CD107a expression by NK cells that increased with the second vaccination and was significantly higher than observed in infected individuals. As expected, vaccine-induced responses were only directed against S1 and not against NC protein. S1-specific CD107a responses by NK cells were significantly correlated to NK cell-mediated killing of S1-expressing cells. Interestingly, screening of serum samples collected prior to the COVID-19 pandemic identified two individuals with cross-reactive antibodies against SARS-CoV-2 S1, which also induced degranulation of NK cells. Taken together, these data demonstrate that antibodies induced by SARS-CoV-2 infection and anti-SARS-CoV-2 vaccines can trigger significant NK cell-mediated ADCC activity, and identify some cross-reactive ADCC-activity against SARS-CoV-2 by endemic coronavirus-specific antibodies. Twit Text FOAVip Natural killer cell-mediated ADCC in SARS-CoV-2-infected individuals and vaccine recipients ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35416291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35416291 #FOAvip English Wikipedia <ref>{{Cite pmid|35416291}}</ref> Natural killer cell-mediated ADCC in SARS-CoV-2-infected individuals and vaccine recipients #MMPMID35416291 Hagemann K; Riecken K; Jung JM; Hildebrandt H; Menzel S; Bunders MJ; Fehse B; Koch-Nolte F; Heinrich F; Peine S; Schulze Zur Wiesch J; Brehm TT; Addo MM; Lutgehetmann M; Altfeld M Eur J Immunol 2022[Aug]; 52 (8): 1297-1307 PMID35416291show ga COVID-19, caused by SARS-CoV-2, has emerged as a global pandemic. While immune responses of the adaptive immune system have been in the focus of research, the role of NK cells in COVID-19 remains less well understood. Here, we characterized NK cell-mediated SARS-CoV-2 antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 spike-1 (S1) and nucleocapsid (NC) protein. Serum samples from SARS-CoV-2 resolvers induced significant CD107a-expression by NK cells in response to S1 and NC, while serum samples from SARS-CoV-2-negative individuals did not. Furthermore, serum samples from individuals that received the BNT162b2 vaccine induced strong CD107a expression by NK cells that increased with the second vaccination and was significantly higher than observed in infected individuals. As expected, vaccine-induced responses were only directed against S1 and not against NC protein. S1-specific CD107a responses by NK cells were significantly correlated to NK cell-mediated killing of S1-expressing cells. Interestingly, screening of serum samples collected prior to the COVID-19 pandemic identified two individuals with cross-reactive antibodies against SARS-CoV-2 S1, which also induced degranulation of NK cells. Taken together, these data demonstrate that antibodies induced by SARS-CoV-2 infection and anti-SARS-CoV-2 vaccines can trigger significant NK cell-mediated ADCC activity, and identify some cross-reactive ADCC-activity against SARS-CoV-2 by endemic coronavirus-specific antibodies. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Antibodies, Viral/metabolism[MESH] |Antibody-Dependent Cell Cytotoxicity[MESH] |BNT162 Vaccine[MESH] |Humans[MESH] |Killer Cells, Natural[MESH]Natural killer cell-mediated ADCC in SARS-CoV-2-infected individuals a(epmc).pdf DeepDyve Pubget Overpricing