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10.3389/fmed.2022.923502 http://scihub22266oqcxt.onion/10.3389/fmed.2022.923502 35783654!9243504!35783654     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35783654.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Med+(Lausanne) 2022 ; 9 (ä): 923502 Nephropedia Template TP {{tp|p=35783654|t=2022. Ketone Bodies Improve Human CD8(+) Cytotoxic T-Cell Immune Response During COVID-19 Infection |pdf=|usr=}}{{35783654}} gab.com Text Ketone Bodies Improve Human CD8(+) Cytotoxic T-Cell Immune Response During COVID-19 Infection JO: Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=35783654 #FOAvip Severe COVID-19 is characterized by profound CD8(+) T-cell dysfunction, which cannot be specifically treated to date. We here investigate whether metabolic CD8(+) T-cell reprogramming by ketone bodies could be a promising strategy to overcome the immunoparalysis in COVID-19 patients. This approach was triggered by our recent pioneering study, which has provided evidence that CD8(+) T-cell capacity in healthy subjects could be significantly empowered by a Ketogenic Diet. These improvements were achieved by immunometabolic rewiring toward oxidative phosphorylation. We here report similar strengthening of CD8(+) T cells obtained from severely diseased COVID-19 patients: Flow cytometry and ELISA revealed elevated cytokine expression and secretion (up to + 24%) upon ketone treatment and enhanced cell lysis capacity (+ 21%). Metabolic analyses using Seahorse technology revealed upregulated mitochondrial respiratory chain activity (+ 25%), enabling both superior energy supply (+ 44%) and higher mitochondrial reactive oxygen species signaling. These beneficial effects of ketones might represent evolutionary conserved mechanisms to strengthen human immunity. Our findings pave the road for metabolic treatment studies in COVID-19. Twit Text FOAVip Ketone Bodies Improve Human CD8(+) Cytotoxic T-Cell Immune Response During COVID-19 Infection ????Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=35783654 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35783654 #FOAvip English Wikipedia <ref>{{Cite pmid|35783654}}</ref> Ketone Bodies Improve Human CD8(+) Cytotoxic T-Cell Immune Response During COVID-19 Infection #MMPMID35783654 Hirschberger S; Gellert L; Effinger D; Muenchhoff M; Herrmann M; Briegel JM; Zwissler B; Kreth S Front Med (Lausanne) 2022[]; 9 (ä): 923502 PMID35783654show ga Severe COVID-19 is characterized by profound CD8(+) T-cell dysfunction, which cannot be specifically treated to date. We here investigate whether metabolic CD8(+) T-cell reprogramming by ketone bodies could be a promising strategy to overcome the immunoparalysis in COVID-19 patients. This approach was triggered by our recent pioneering study, which has provided evidence that CD8(+) T-cell capacity in healthy subjects could be significantly empowered by a Ketogenic Diet. These improvements were achieved by immunometabolic rewiring toward oxidative phosphorylation. We here report similar strengthening of CD8(+) T cells obtained from severely diseased COVID-19 patients: Flow cytometry and ELISA revealed elevated cytokine expression and secretion (up to + 24%) upon ketone treatment and enhanced cell lysis capacity (+ 21%). Metabolic analyses using Seahorse technology revealed upregulated mitochondrial respiratory chain activity (+ 25%), enabling both superior energy supply (+ 44%) and higher mitochondrial reactive oxygen species signaling. These beneficial effects of ketones might represent evolutionary conserved mechanisms to strengthen human immunity. Our findings pave the road for metabolic treatment studies in COVID-19. äKetone Bodies Improve Human CD8(+) Cytotoxic T-Cell Immune Response Du(epmc).pdf DeepDyve Pubget Overpricing