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10.3390/ijms23137365

http://scihub22266oqcxt.onion/10.3390/ijms23137365
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35806369!9266613!35806369
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suck abstract from ncbi


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pmid35806369      Int+J+Mol+Sci 2022 ; 23 (13): ä
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  • Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2 #MMPMID35806369
  • Zhang C; Meng X; Zhao H
  • Int J Mol Sci 2022[Jul]; 23 (13): ä PMID35806369show ga
  • Virus-cell fusion is the key step for viral infection in host cells. Studies on virus binding and fusion with host cells are important for understanding the virus-host interaction and viral pathogenesis for the discovery of antiviral drugs. In this review, we focus on the virus-cell fusions induced by the two major pandemic viruses, including the influenza virus and SARS-CoV-2. We further compare the cell fusions induced by the influenza virus and SARS-CoV-2, especially the pH-dependent fusion of the influenza virus and the fusion of SARS-CoV-2 in the type-II transmembrane serine protease 2 negative (TMPRSS2(-)) cells with syncytia formation. Finally, we present the development of drugs used against SARA-CoV-2 and the influenza virus through the discovery of anti-fusion drugs and the prevention of pandemic respiratory viruses.
  • |*COVID-19[MESH]
  • |*Orthomyxoviridae/metabolism[MESH]
  • |Cell Fusion[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2[MESH]
  • |Spike Glycoprotein, Coronavirus/metabolism[MESH]


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