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Hypoxia-inducible factor 1 alpha (HIF-1alpha) stimulated and P2X7 receptor activated by COVID-19, as a potential therapeutic target and risk factor for epilepsy #MMPMID35831562
Zalpoor H; Akbari A; Nabi-Afjadi M; Forghaniesfidvajani R; Tavakol C; Barzegar Z; Iravanpour F; Hosseini M; Mousavi SR; Farrokhi MR
Hum Cell 2022[Sep]; 35 (5): 1338-1345 PMID35831562show ga
Based on available evidence, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a neuroinvasive virus. According to the centers for disease control and prevention (CDC), coronavirus disease 2019 (COVID-19) may cause epilepsy. In this line, COVID-19 can stimulate hypoxia-inducible factor-1 alpha (HIF-1alpha) and activate P2X7 receptor. Both HIF-1alpha and P2X7 receptors are linked to epileptogenesis and seizures. Therefore, in the current study, we suggested that COVID-19 may have a role in epileptogenesis and seizure through HIF-1alpha stimulation and P2X7 receptor activation. Consequently, pharmacological targeting of these factors could be a promising therapeutic approach for such patients.