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Hypoxia-inducible factor-1alpha and ischemia-modified albumin levels in intensive care COVID-19 Patients #MMPMID35851469
OBJECTIVES: In this study, it was aimed to evaluate the hypoxia-inducible factor-1alpha (HIF-1alpha) and ischemia-modified albumin (IMA) levels of patients diagnosed with COVID-19 in the intensive care unit (ICU) and healthy controls. To our knowledge, this is the first study investigate HIF-1alpha and IMA levels in COVID-19 patients in ICUs and comparing them with a healthy control group. For this reason, our study is original and will contribute to the literature. METHODS: A total of 70 intensive care patients diagnosed with COVID-19, and 72 healthy controls were included in the study. RESULTS: When we compared the patient and healthy control group; there were no statistically significant differences between the groups in terms of age and gender (p>0.05). No exitus was observed in the patient group. We found weak correlation between HIF-1alpha and IMA (r: 0.320). However, there were statistically significant differences in HIF-1alpha and IMA levels in the patient group. The receiver operating characteristic (ROC) curve demonstrated an area under curve (AUC) value of 0.651 for HIF-1alpha and 0.937 for IMA. CONCLUSIONS: The HIF-1alpha and IMA levels were significantly higher among COVID-19 patients in ICU compared with healthy controls. HIF-1alpha and IMA levels can be used as reliable markers for the prognosis of COVID-19.