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10.1016/j.celrep.2022.111148 http://scihub22266oqcxt.onion/10.1016/j.celrep.2022.111148 35858624!9279298!35858624     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35858624.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2022 ; 40 (4): 111148 Nephropedia Template TP {{tp|p=35858624|t=2022. Plasmacytoid dendritic cells during COVID-19: Ally or adversary?|pdf=|usr=}}{{35858624}} gab.com Text Plasmacytoid dendritic cells during COVID-19: Ally or adversary JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=35858624 #FOAvip Plasmacytoid dendritic cells (pDCs) are specialized cells of the immune system that are thought to be the main cellular source of type I interferon alpha (IFNalpha) in response to viral infections. IFNs are powerful antivirals, whereas defects in their function or induction lead to impaired resistance to virus infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19. IFN production needs to be controlled, because sustained IFN production can also have detrimental effects on disease outcome. As such, pDCs are likely important for acute antiviral protection against SARS-CoV-2 infection but could potentially also contribute to chronic IFN levels. Here, we provide a historical overview of pDC biology and summarize existing literature addressing their involvement and importance during viral infections of the airways. Furthermore, we outline recent reports focused on the potential role of pDCs during SARS-CoV-2 infection, as well as the potential for this cellular subset to impact COVID-19 disease outcome. Twit Text FOAVip Plasmacytoid dendritic cells during COVID-19: Ally or adversary ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=35858624 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35858624 #FOAvip English Wikipedia <ref>{{Cite pmid|35858624}}</ref> Plasmacytoid dendritic cells during COVID-19: Ally or adversary? #MMPMID35858624 Van der Sluis RM; Holm CK; Jakobsen MR Cell Rep 2022[Jul]; 40 (4): 111148 PMID35858624show ga Plasmacytoid dendritic cells (pDCs) are specialized cells of the immune system that are thought to be the main cellular source of type I interferon alpha (IFNalpha) in response to viral infections. IFNs are powerful antivirals, whereas defects in their function or induction lead to impaired resistance to virus infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19. IFN production needs to be controlled, because sustained IFN production can also have detrimental effects on disease outcome. As such, pDCs are likely important for acute antiviral protection against SARS-CoV-2 infection but could potentially also contribute to chronic IFN levels. Here, we provide a historical overview of pDC biology and summarize existing literature addressing their involvement and importance during viral infections of the airways. Furthermore, we outline recent reports focused on the potential role of pDCs during SARS-CoV-2 infection, as well as the potential for this cellular subset to impact COVID-19 disease outcome. |*COVID-19[MESH] |*Interferon Type I[MESH] |Antiviral Agents/pharmacology[MESH] |Dendritic Cells[MESH] |Humans[MESH]Plasmacytoid dendritic cells during COVID-19: Ally or adversary?(epmc).pdf DeepDyve Pubget Overpricing