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10.2174/1568026622666220726122339 http://scihub22266oqcxt.onion/10.2174/1568026622666220726122339 35894476!ä!35894476 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35894476.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Top+Med+Chem 2022 ; 22 (21): 1776-1792 Nephropedia Template TP {{tp|p=35894476|t=2022. Host Cell Proteases Mediating SARS-CoV-2 Entry: An Overview |pdf=|usr=}}{{35894476}} gab.com Text Host Cell Proteases Mediating SARS-CoV-2 Entry: An Overview JO: Curr Top Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=35894476 #FOAvip The outbreak of the SARS-CoV-2 virus in late 2019 and the spread of the COVID-19 pandemic have caused severe health and socioeconomic damage worldwide. Despite the significant research effort to develop vaccines, antiviral treatments, and repurposed therapeutics to effectively contain the catastrophe, there are no available effective vaccines or antiviral drugs that can limit the threat of the disease, so the infections continue to expand. To date, the search for effective treatment remains a global challenge. Therefore, it is imperative to develop therapeutic strategies to contain the spread of SARS-CoV-2. Like other coronaviruses, SARS-CoV-2 invades and infects human host cells via the attachment of its spike envelope glycoprotein to the human host cell receptor hACE2. Subsequently, several host cell proteases facilitate viral entry via proteolytic cleavage and activation of the S protein. These host cell proteases include type II transmembrane serine proteases (TTSPs), cysteine cathepsins B and L, furin, trypsin, and Factor Xa, among others. Given the critical role of the host cell proteases in coronavirus pathogenesis, their inhibition by small molecules has successfully targeted SARS-CoV-2 in vitro, suggesting that host cell proteases are attractive therapeutic targets for SARS-CoV-2 infection. In this review, we focus on the biochemical properties of host cell proteases that facilitate the entry of SARS-CoV-2, and we highlight therapeutic small molecule candidates that have been proposed through in silico research. Twit Text FOAVip Host Cell Proteases Mediating SARS-CoV-2 Entry: An Overview ????Curr Top Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=35894476 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35894476 #FOAvip English Wikipedia <ref>{{Cite pmid|35894476}}</ref> Host Cell Proteases Mediating SARS-CoV-2 Entry: An Overview #MMPMID35894476 Oubahmane M; Hdoufane I; Bjij I; Lahcen NA; Villemin D; Daoud R; Allali AE; Cherqaoui D Curr Top Med Chem 2022[]; 22 (21): 1776-1792 PMID35894476show ga The outbreak of the SARS-CoV-2 virus in late 2019 and the spread of the COVID-19 pandemic have caused severe health and socioeconomic damage worldwide. Despite the significant research effort to develop vaccines, antiviral treatments, and repurposed therapeutics to effectively contain the catastrophe, there are no available effective vaccines or antiviral drugs that can limit the threat of the disease, so the infections continue to expand. To date, the search for effective treatment remains a global challenge. Therefore, it is imperative to develop therapeutic strategies to contain the spread of SARS-CoV-2. Like other coronaviruses, SARS-CoV-2 invades and infects human host cells via the attachment of its spike envelope glycoprotein to the human host cell receptor hACE2. Subsequently, several host cell proteases facilitate viral entry via proteolytic cleavage and activation of the S protein. These host cell proteases include type II transmembrane serine proteases (TTSPs), cysteine cathepsins B and L, furin, trypsin, and Factor Xa, among others. Given the critical role of the host cell proteases in coronavirus pathogenesis, their inhibition by small molecules has successfully targeted SARS-CoV-2 in vitro, suggesting that host cell proteases are attractive therapeutic targets for SARS-CoV-2 infection. In this review, we focus on the biochemical properties of host cell proteases that facilitate the entry of SARS-CoV-2, and we highlight therapeutic small molecule candidates that have been proposed through in silico research. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Antiviral Agents/pharmacology[MESH] |Humans[MESH] |Pandemics[MESH] |Peptide Hydrolases/metabolism[MESH] |Spike Glycoprotein, Coronavirus/chemistry[MESH]Host Cell Proteases Mediating SARS-CoV-2 Entry: An Overview (epmc).pdf DeepDyve Pubget Overpricing