Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4049/jimmunol.2200021 http://scihub22266oqcxt.onion/10.4049/jimmunol.2200021 35896335!ä!35896335 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35896335.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2022 ; 209 (4): 655-659 Nephropedia Template TP {{tp|p=35896335|t=2022. Cutting Edge: Hyperinflammatory Monocytes Expressing CD56 Abound in Severe COVID-19 Patients |pdf=|usr=}}{{35896335}} gab.com Text Cutting Edge: Hyperinflammatory Monocytes Expressing CD56 Abound in Severe COVID-19 Patients JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35896335 #FOAvip Proinflammatory monocytes play a preponderant role in the development of a cytokine storm causing fatal consequences in coronavirus disease 2019 (COVID-19) patients, highlighting the importance of analyzing in more detail monocyte distribution in these patients. In this study, we identified an atypical monocyte subpopulation expressing CD56 molecules that showed a low level of HLA-DR and high level of l-selectin. They released higher amounts of TNF-alpha and IL-6 and expressed genes associated with an excessive inflammatory process. Remarkably, the frequency of CD56(+) monocytes inversely correlated with that of CD16(+) monocytes and a high CD56(+)/CD16(+)monocyte ratio was associated with both disease severity and mortality, as well as with serum concentration of type I IFN, a factor able to induce the appearance of CD56(+) monocytes. In conclusion, severe COVID-19 is characterized by the abundance of hyperinflammatory CD56(+) monocytes, which could represent a novel marker with prognostic significance and, possibly, a therapeutic target for controlling the inflammatory process occurring during COVID-19. Twit Text FOAVip Cutting Edge: Hyperinflammatory Monocytes Expressing CD56 Abound in Severe COVID-19 Patients ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35896335 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35896335 #FOAvip English Wikipedia <ref>{{Cite pmid|35896335}}</ref> Cutting Edge: Hyperinflammatory Monocytes Expressing CD56 Abound in Severe COVID-19 Patients #MMPMID35896335 Campana S; De Pasquale C; Sidoti Migliore G; Pezzino G; Cavaliere R; Venanzi Rullo E; Nunnari G; Caramori G; David A; Bonaccorsi I; Pollicino T; Carrega P; Ferlazzo G J Immunol 2022[Aug]; 209 (4): 655-659 PMID35896335show ga Proinflammatory monocytes play a preponderant role in the development of a cytokine storm causing fatal consequences in coronavirus disease 2019 (COVID-19) patients, highlighting the importance of analyzing in more detail monocyte distribution in these patients. In this study, we identified an atypical monocyte subpopulation expressing CD56 molecules that showed a low level of HLA-DR and high level of l-selectin. They released higher amounts of TNF-alpha and IL-6 and expressed genes associated with an excessive inflammatory process. Remarkably, the frequency of CD56(+) monocytes inversely correlated with that of CD16(+) monocytes and a high CD56(+)/CD16(+)monocyte ratio was associated with both disease severity and mortality, as well as with serum concentration of type I IFN, a factor able to induce the appearance of CD56(+) monocytes. In conclusion, severe COVID-19 is characterized by the abundance of hyperinflammatory CD56(+) monocytes, which could represent a novel marker with prognostic significance and, possibly, a therapeutic target for controlling the inflammatory process occurring during COVID-19. |*COVID-19[MESH] |*Monocytes[MESH] |Cytokine Release Syndrome[MESH] |HLA-DR Antigens[MESH] |Humans[MESH] |Receptors, IgG/genetics[MESH]Cutting Edge: Hyperinflammatory Monocytes Expressing CD56 Abound in Se(epmc).pdf DeepDyve Pubget Overpricing