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10.1021/acs.est.2c02311

http://scihub22266oqcxt.onion/10.1021/acs.est.2c02311
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35904357!ä!35904357

suck abstract from ncbi


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pmid35904357      Environ+Sci+Technol 2023 ; 57 (46): 17737-17750
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  • Virus Dynamics and Decay in Evaporating Human Saliva Droplets on Fomites #MMPMID35904357
  • Kong ZM; Sandhu HS; Qiu L; Wu J; Tian WJ; Chi XJ; Tao Z; Yang CJ; Wang XJ
  • Environ Sci Technol 2023[Nov]; 57 (46): 17737-17750 PMID35904357show ga
  • The transmission of most respiratory pathogens, including SARS-CoV-2, occurs via virus-containing respiratory droplets, and thus, factors that affect virus viability in droplet residues on surfaces are of critical medical and public health importance. Relative humidity (RH) is known to play a role in virus survival, with a U-shaped relationship between RH and virus viability. The mechanisms affecting virus viability in droplet residues, however, are unclear. This study examines the structure and evaporation dynamics of virus-containing saliva droplets on fomites and their impact on virus viability using four model viruses: vesicular stomatitis virus, herpes simplex virus 1, Newcastle disease virus, and coronavirus HCoV-OC43. The results support the hypothesis that the direct contact of antiviral proteins and virions within the "coffee ring" region of the droplet residue gives rise to the observed U-shaped relationship between virus viability and RH. Viruses survive much better at low and high RH, and their viability is substantially reduced at intermediate RH. A phenomenological theory explaining this phenomenon and a quantitative model analyzing and correlating the experimentally measured virus survivability are developed on the basis of the observations. The mechanisms by which RH affects virus viability are explored. At intermediate RH, antiviral proteins have optimal influence on virions because of their largest contact time and overlap area, which leads to the lowest level of virus activity.
  • |*Fomites[MESH]
  • |*Viruses[MESH]
  • |Animals[MESH]
  • |Antiviral Agents[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2[MESH]


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