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10.1007/BF00542411

http://scihub22266oqcxt.onion/10.1007/BF00542411
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3758141!ä!3758141

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suck abstract from ncbi


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pmid3758141      Eur+J+Clin+Pharmacol 1986 ; 30 (5): 535-40
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  • Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial hypertension #MMPMID3758141
  • Dyckner T; Wester PO; Widman L
  • Eur J Clin Pharmacol 1986[]; 30 (5): 535-40 PMID3758141show ga
  • The effect of adding spironolactone (Aldactone) on muscle electrolytes was studied in 48 patients with arterial hypertension and/or congestive heart failure who had received conventional diuretic treatment, including a potassium supplement, for more than 1 year. After 6 months on spironolactone 100 mg/day as well as the original conventional diuretic therapy, there was a significant increase in both skeletal muscle potassium and magnesium. At the same time these parameters decreased in the control group. In the spironolactone group there was also a significant increase in the mean serum potassium and creatinine levels. There was a significant fall in blood pressure in the spironolactone-treated group.
  • |Aged[MESH]
  • |Blood Pressure/drug effects[MESH]
  • |Body Weight/drug effects[MESH]
  • |Diuretics/*adverse effects/therapeutic use[MESH]
  • |Electrolytes/blood/*metabolism[MESH]
  • |Female[MESH]
  • |Heart Failure/complications/drug therapy/*metabolism[MESH]
  • |Humans[MESH]
  • |Hypertension/complications/drug therapy/*metabolism[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Muscles/*metabolism[MESH]
  • |Potassium/metabolism[MESH]


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