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10.2131/jts.49.409 http://scihub22266oqcxt.onion/10.2131/jts.49.409 39231685!ä!39231685 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Toxicol+Sci 2024 ; 49 (9): 409-423 Nephropedia Template TP {{tp|p=39231685|t=2024. Comparative sensitivity of laboratory animals used for preclinical convulsion risk assessment to drug-induced convulsion |pdf=|usr=}}{{39231685}} gab.com Text Comparative sensitivity of laboratory animals used for preclinical convulsion risk assessment to drug-induced convulsion JO: J Toxicol Sci http://www.kidney.de/pget.php?&tw=1&pmid=39231685 #FOAvip Drug-induced convulsion is a serious concern in drug development, such that the convulsion liability of drug candidates must be evaluated in preclinical safety studies. However, information on the differences among species regarding their sensitivity to convulsions induced by convulsant drugs in humans remains limited. Here, we selected 11 test articles from several pharmacological classes and compared the sensitivities of three types of laboratory animal to convulsion. All 11 test articles were examined in mice via intraperitoneal injection and in rats via intravenous bolus; and 6 of the 11 test articles, selected mainly based on availabilities of data on drug plasma concentrations in humans at convulsion, were examined in non-human primates (NHPs) via intravenous infusion. Plasma concentrations of the test articles shortly after convulsion onset or 5 min after administration were measured. All 11 articles tested in mice, 10 of 11 articles tested in rats, and all 6 articles tested in NHPs induced convulsion with premonitory signs. Although there was a general tendency that rats and NHPs exhibited convulsions at lower plasma drug concentrations than did mice, the plasma concentrations at convulsion onset were generally comparable, within 3-fold differences, across the animal species. We conclude that the mice, rats, and NHPs examined in the present study generally showed similar sensitivities to convulsion induced by the test articles. Thus, each of these laboratory animals can be used for the assessment of convulsion risk in the early stages of drug development, depending on throughput, cost, and test article-specific requirements. Twit Text FOAVip Comparative sensitivity of laboratory animals used for preclinical convulsion risk assessment to drug-induced convulsion ????J Toxicol Sci http://www.kidney.de/pget.php?&tw=1&pmid=39231685 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=39231685 #FOAvip English Wikipedia <ref>{{Cite pmid|39231685}}</ref> Comparative sensitivity of laboratory animals used for preclinical convulsion risk assessment to drug-induced convulsion #MMPMID39231685 Shiotani M; Seki Y; Takano M; Ishihara H; Mikamoto M; Nozaki Y; Maeda S; Taniguchi T; Miyamoto N; Yoshinaga T; Asakura S J Toxicol Sci 2024[]; 49 (9): 409-423 PMID39231685show ga Drug-induced convulsion is a serious concern in drug development, such that the convulsion liability of drug candidates must be evaluated in preclinical safety studies. However, information on the differences among species regarding their sensitivity to convulsions induced by convulsant drugs in humans remains limited. Here, we selected 11 test articles from several pharmacological classes and compared the sensitivities of three types of laboratory animal to convulsion. All 11 test articles were examined in mice via intraperitoneal injection and in rats via intravenous bolus; and 6 of the 11 test articles, selected mainly based on availabilities of data on drug plasma concentrations in humans at convulsion, were examined in non-human primates (NHPs) via intravenous infusion. Plasma concentrations of the test articles shortly after convulsion onset or 5 min after administration were measured. All 11 articles tested in mice, 10 of 11 articles tested in rats, and all 6 articles tested in NHPs induced convulsion with premonitory signs. Although there was a general tendency that rats and NHPs exhibited convulsions at lower plasma drug concentrations than did mice, the plasma concentrations at convulsion onset were generally comparable, within 3-fold differences, across the animal species. We conclude that the mice, rats, and NHPs examined in the present study generally showed similar sensitivities to convulsion induced by the test articles. Thus, each of these laboratory animals can be used for the assessment of convulsion risk in the early stages of drug development, depending on throughput, cost, and test article-specific requirements. |*Drug Evaluation, Preclinical[MESH] |*Seizures/chemically induced[MESH] |*Species Specificity[MESH] |Animals[MESH] |Animals, Laboratory[MESH] |Convulsants/toxicity[MESH] |Humans[MESH] |Injections, Intraperitoneal[MESH] |Male[MESH] |Mice[MESH] |Rats[MESH]Comparative sensitivity of laboratory animals used for preclinical con(epmc).pdf DeepDyve Pubget Overpricing