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10.2186/jpr.JPR_D_23_00309 http://scihub22266oqcxt.onion/10.2186/jpr.JPR_D_23_00309 39231696!ä!39231696 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Prosthodont+Res 2025 ; 69 (1): 97-109 Nephropedia Template TP {{tp|p=39231696|t=2025. Single-cell analysis of peri-implant gingival tissue to assess implant biocompatibility and immune response |pdf=|usr=}}{{39231696}} gab.com Text Single-cell analysis of peri-implant gingival tissue to assess implant biocompatibility and immune response JO: J Prosthodont Res http://www.kidney.de/pget.php?&tw=1&pmid=39231696 #FOAvip PURPOSE: The innate immune response, particularly the reaction of polymorphonuclear neutrophils (PMNs), is crucial in shaping the outcomes of chronic inflammation, fibrosis, or osseointegration following biomaterial implantation. Peri-implantitis or peri-implant mucositis, inflammatory conditions linked to dental implants, pose a significant threat to implant success. We developed a single-cell analysis approach using a murine model to assess the immune response to implant materials, offering a practical screening tool for potential dental implants. METHODS: We performed bioinformatics analysis and established a peri-implant inflammation model by inserting two titanium implants into the maxillary region, to examine the immune response. RESULTS: Bioinformatics analysis revealed that titanium implants triggered a host immune response, primarily mediated by PMNs. In the in vivo experiments, we observed a rapid PMN-mediated response, with increased infiltration around the implants and on the implant surface by day 3. Remarkably, PMN attachment to the implants persisted for 7 days, resembling the immune profiles seen in human implant-mediated inflammation. CONCLUSIONS: Our findings indicate that persistent attachment of the short-living PMNs to titanium implants can serve as an indicator or traits of peri-implant inflammation. Therefore, analyzing gingival tissue at the single-cell level could be a useful tool for evaluating the biocompatibility of candidate dental implants. Twit Text FOAVip Single-cell analysis of peri-implant gingival tissue to assess implant biocompatibility and immune response ????J Prosthodont Res http://www.kidney.de/pget.php?&tw=1&pmid=39231696 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=39231696 #FOAvip English Wikipedia <ref>{{Cite pmid|39231696}}</ref> Single-cell analysis of peri-implant gingival tissue to assess implant biocompatibility and immune response #MMPMID39231696 Wang LT; Juang SE; Chang HH; He AC; Chen WA; Huang YW; Van Dyke TE; Ma KS; Chen YW J Prosthodont Res 2025[Jan]; 69 (1): 97-109 PMID39231696show ga PURPOSE: The innate immune response, particularly the reaction of polymorphonuclear neutrophils (PMNs), is crucial in shaping the outcomes of chronic inflammation, fibrosis, or osseointegration following biomaterial implantation. Peri-implantitis or peri-implant mucositis, inflammatory conditions linked to dental implants, pose a significant threat to implant success. We developed a single-cell analysis approach using a murine model to assess the immune response to implant materials, offering a practical screening tool for potential dental implants. METHODS: We performed bioinformatics analysis and established a peri-implant inflammation model by inserting two titanium implants into the maxillary region, to examine the immune response. RESULTS: Bioinformatics analysis revealed that titanium implants triggered a host immune response, primarily mediated by PMNs. In the in vivo experiments, we observed a rapid PMN-mediated response, with increased infiltration around the implants and on the implant surface by day 3. Remarkably, PMN attachment to the implants persisted for 7 days, resembling the immune profiles seen in human implant-mediated inflammation. CONCLUSIONS: Our findings indicate that persistent attachment of the short-living PMNs to titanium implants can serve as an indicator or traits of peri-implant inflammation. Therefore, analyzing gingival tissue at the single-cell level could be a useful tool for evaluating the biocompatibility of candidate dental implants. |*Biocompatible Materials[MESH] |*Dental Implants[MESH] |*Gingiva/immunology[MESH] |*Neutrophils/immunology[MESH] |*Peri-Implantitis/immunology/etiology[MESH] |*Single-Cell Analysis[MESH] |*Titanium[MESH] |Animals[MESH] |Computational Biology[MESH] |Immunity, Innate[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH]Single-cell analysis of peri-implant gingival tissue to assess implant(epmc).pdf DeepDyve Pubget Overpricing