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10.1016/0002-9149(86)90813-1

http://scihub22266oqcxt.onion/10.1016/0002-9149(86)90813-1
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3953430!ä!3953430

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suck abstract from ncbi


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pmid3953430      Am+J+Cardiol 1986 ; 57 (7): 83D-86D
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  • Short- and long-term treatment of mild to moderate hypertension with verapamil #MMPMID3953430
  • Wicker P; Roudaut R; Gosse P; Dallocchio M
  • Am J Cardiol 1986[Feb]; 57 (7): 83D-86D PMID3953430show ga
  • Forty-three patients with mild to moderate hypertension (supine diastolic blood pressure 95 to 115 mm Hg) were entered into a short-term (3 months) study. All received verapamil, 120 mg 3 times a day. After 1 month of treatment on verapamil alone, supine diastolic blood pressure was normalized (less than 95 mm Hg) in 29 patients (67%). These patients continued with verapamil at the same dosage. In 14 nonresponders (supine diastolic blood pressure greater than 95 mm Hg) a combination of althiazide (15 mg/day) and spironolactone (25 mg/day) was added. This resulted in diastolic blood pressure normalization in 9 additional patients. Verapamil induced a slight but moderate decrease in heart rate after 1 month, but no further decrease was observed thereafter. During the trial, 21% of patients reported adverse effects, mostly transient and mild. No patient had to discontinue treatment because of them. Twenty-six patients on verapamil alone were followed for 1 year. Systolic and diastolic blood pressure was adequately controlled in all patients except 1. In 13 the dosage was decreased to 120 mg 2 times a day. There were no significant differences in blood pressure between this group and patients given 120 mg 3 times a day. It is concluded that verapamil is an effective and safe antihypertensive agent in mildly to moderately hypertensive patients. Because a dosage of 120 mg 2 times a day was as effective as 120 mg 3 times a day, the former should be recommended, as it may improve patient compliance.
  • |Blood Pressure/drug effects[MESH]
  • |Drug Administration Schedule[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Female[MESH]
  • |Heart Rate/drug effects[MESH]
  • |Humans[MESH]
  • |Hypertension/*drug therapy[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Time Factors[MESH]


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