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The effect of spironolactone on the arterial water, cation, and norepinephrine contents of control and one-kidney-one-clip hypertensive dogs #MMPMID487270
Constantopoulos G; Gutkowska J; Genest J
Can J Physiol Pharmacol 1979[Jun]; 57 (6): 631-6 PMID487270show ga
Spironolactone at 10 mg per kilogram per day was given to control and 'one-kidney-one-clip' hypertensive dogs for 6--7 weeks. Compared with untreated animals the treated animals had a lower arterial water content, a higher arterial, myocardial, and skeletal muscle sodium content, and variable changes in tissue potassium concentrations.