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Elektronno-mikroskopicheskoe issledovanie vzaimodeistviia virusa grippa s peritoneal'nymi myshinymi makrofagami #MMPMID602148
Shushkov IS; Lazarenko VN; Kosiakov PN; Klimenko SM
Vopr Virusol 1977[Nov]; ä (6): 698-703 PMID602148show ga
Electron microscopic study of mouse peritoneal macrophages infected with influenza virus showed typical phenomena of phagocytosis (absorption, invagination of plasma membrane, and formation of phagosomes) to occur at early stages of virus-cell interaction, up to 2 hours. At later stages, from 3 to 24 hours postinfection, virus particles were completely absent and virus antigen was present in most cells indicating the distruction of phagocytized virus. These observations confirm an important role of macrophages in antiviral immunity.