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10.1016/0002-9149(84)90827-0 http://scihub22266oqcxt.onion/10.1016/0002-9149(84)90827-0 6421137!ä!6421137 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\6421137.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Cardiol 1984 ; 53 (3): 9A-11A Nephropedia Template TP {{tp|p=6421137|t=1984. Diuretic therapy for mild hypertension: the "real" cost of treatment |pdf=|usr=}}{{6421137}} gab.com Text Diuretic therapy for mild hypertension: the "real" cost of treatment JO: Am J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=6421137 #FOAvip The benefit of any medical intervention, particularly drug therapy, must be weighed against its cost. These costs are not only dollar expenditures but effects on lifestyle and overall health. Diuretic therapy for hypertension has been in use long enough to allow long-term clinical evaluation. It is clear from the numerous prospective drug intervention trials involving hypertensive patients that diuretic therapy is not free of "costs." Aside from the fact that 15 to 20% of diuretic-treated patients reportedly drop out of trials because of side effects, including exertional dyspnea, fatigability, lethargy and impotence, numerous metabolic derangements have been reported with these drugs, i.e., potassium, uric acid, lipid, sodium, glucose and magnesium alterations. Perhaps most important are the changes in lipid fractions, which may be responsible for the failure of antihypertensive therapy to decrease the risk of coronary heart disease. Thus, although diuretics are somewhat less expensive than other antihypertensive drugs in terms of dollars, their overall costs are high. The major alternatives, such as the alpha-blocker prazosin or the central nervous system agent clonidine, are preferable, do not impair a patient's lifestyle and are recommended to be used along with changes in diet and an exercise program for control of mild to moderate hypertension. Twit Text FOAVip Diuretic therapy for mild hypertension: the "real" cost of treatment ????Am J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=6421137 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=6421137 #FOAvip English Wikipedia <ref>{{Cite pmid|6421137}}</ref> Diuretic therapy for mild hypertension: the "real" cost of treatment #MMPMID6421137 McCarron DA Am J Cardiol 1984[Jan]; 53 (3): 9A-11A PMID6421137show ga The benefit of any medical intervention, particularly drug therapy, must be weighed against its cost. These costs are not only dollar expenditures but effects on lifestyle and overall health. Diuretic therapy for hypertension has been in use long enough to allow long-term clinical evaluation. It is clear from the numerous prospective drug intervention trials involving hypertensive patients that diuretic therapy is not free of "costs." Aside from the fact that 15 to 20% of diuretic-treated patients reportedly drop out of trials because of side effects, including exertional dyspnea, fatigability, lethargy and impotence, numerous metabolic derangements have been reported with these drugs, i.e., potassium, uric acid, lipid, sodium, glucose and magnesium alterations. Perhaps most important are the changes in lipid fractions, which may be responsible for the failure of antihypertensive therapy to decrease the risk of coronary heart disease. Thus, although diuretics are somewhat less expensive than other antihypertensive drugs in terms of dollars, their overall costs are high. The major alternatives, such as the alpha-blocker prazosin or the central nervous system agent clonidine, are preferable, do not impair a patient's lifestyle and are recommended to be used along with changes in diet and an exercise program for control of mild to moderate hypertension. |*Benzothiadiazines[MESH] |Aged[MESH] |Clinical Trials as Topic[MESH] |Clonidine/therapeutic use[MESH] |Cost-Benefit Analysis[MESH] |Diet[MESH] |Diuretics[MESH] |Humans[MESH] |Hypertension/*drug therapy/economics[MESH] |Life Style[MESH] |Middle Aged[MESH] |Physical Exertion[MESH] |Prazosin/therapeutic use[MESH] |Prospective Studies[MESH] |Sodium Chloride Symporter Inhibitors/adverse effects/*therapeutic use[MESH]Diuretic therapy for mild hypertension: the "real" cost of treatment (epmc).pdf DeepDyve Pubget Overpricing