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Magnesium 1984 ; 3 (4-6): 248-56 Nephropedia Template TP
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Mode of action of conventional and potassium-sparing diuretics--aspects with relevance to Mg-sparing effects Review of the present state of the art and recent findings #MMPMID6536835Heidenreich OMagnesium 1984[]; 3 (4-6): 248-56 PMID6536835show ga
The sites and modes of action of five groups of diuretics within the nephron, and their effects on magnesium excretion are outlined. More than 60% of the glomerularly filtered magnesium is reabsorbed in the loop of Henle. Hence, the loop diuretics induce a strong magnesium excretion. The benzothiadiazine diuretics increase magnesium excretion only moderately. In contrast, the potassium-sparing diuretics amiloride and triamterene, as well as the aldosterone antagonists, increase magnesium reabsorption and therefore may be designated as magnesium-conserving diuretic drugs. The possible modes of action of this property are discussed.|Amiloride/pharmacology[MESH]|Animals[MESH]|Biological Transport/drug effects[MESH]|Diuretics/*pharmacology[MESH]|Furosemide/pharmacology[MESH]|Humans[MESH]|Kidney/*drug effects/physiology[MESH]|Kinetics[MESH]|Magnesium/*metabolism/urine[MESH]|Models, Biological[MESH]|Nephrons/drug effects[MESH]|Potassium/*metabolism[MESH]
  
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