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pmid6536835      Magnesium 1984 ; 3 (4-6): 248-56
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  • Mode of action of conventional and potassium-sparing diuretics--aspects with relevance to Mg-sparing effects Review of the present state of the art and recent findings #MMPMID6536835
  • Heidenreich O
  • Magnesium 1984[]; 3 (4-6): 248-56 PMID6536835show ga
  • The sites and modes of action of five groups of diuretics within the nephron, and their effects on magnesium excretion are outlined. More than 60% of the glomerularly filtered magnesium is reabsorbed in the loop of Henle. Hence, the loop diuretics induce a strong magnesium excretion. The benzothiadiazine diuretics increase magnesium excretion only moderately. In contrast, the potassium-sparing diuretics amiloride and triamterene, as well as the aldosterone antagonists, increase magnesium reabsorption and therefore may be designated as magnesium-conserving diuretic drugs. The possible modes of action of this property are discussed.
  • |Amiloride/pharmacology[MESH]
  • |Animals[MESH]
  • |Biological Transport/drug effects[MESH]
  • |Diuretics/*pharmacology[MESH]
  • |Furosemide/pharmacology[MESH]
  • |Humans[MESH]
  • |Kidney/*drug effects/physiology[MESH]
  • |Kinetics[MESH]
  • |Magnesium/*metabolism/urine[MESH]
  • |Models, Biological[MESH]
  • |Nephrons/drug effects[MESH]
  • |Potassium/*metabolism[MESH]


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