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10.1172/JCI117592 http://scihub22266oqcxt.onion/10.1172/JCI117592 7989584!330056!7989584     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=7989584&cmd=llinks): Failed to open stream: HTTP request failed! 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Activation of potassium channels contributes to hypoxic injury in proximal tubules |pdf=|usr=}}{{7989584}} gab.com Text Activation of potassium channels contributes to hypoxic injury in proximal tubules JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=7989584 #FOAvip The mechanisms responsible for the loss of cell potassium during renal ischemia are poorly understood. The present studies examined the hypothesis that potassium channels are activated as an early response to hypoxia and contribute to potassium loss independent from an inhibition of active K+ uptake. Potassium flux in suspensions of freshly isolated rat proximal tubules was measured using an ion-selective electrode. Exposure of the tubules to hypoxia for only 2.5 min resulted in a rise in the passive leak rate of K+ but no decrease in active K+ uptake. The passive leak of K+ was associated with a 40% decrease in cell ATP content. The passive K+ efflux was inhibited by 5 mM Ba2+ (95%) and by 15 mM tetraethylammonium (85%) suggesting that K+ channels were the primary route of K+ movement. The effects of K+ channel blockade on the development of hypoxic injury were also examined. Tetraethylammonium and glibenclamide, an inhibitor of ATP-sensitive K+ channels, reduced hypoxic injury as assessed by the release of lactate dehydrogenase or measurement of DNA damage. These results suggest that activation of K+ channels is an early response to hypoxia and contributes to hypoxic renal injury. Twit Text FOAVip Activation of potassium channels contributes to hypoxic injury in proximal tubules ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=7989584 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=7989584 #FOAvip English Wikipedia <ref>{{Cite pmid|7989584}}</ref> Activation of potassium channels contributes to hypoxic injury in proximal tubules #MMPMID7989584 Reeves WB; Shah SV J Clin Invest 1994[Dec]; 94 (6): 2289-94 PMID7989584show ga The mechanisms responsible for the loss of cell potassium during renal ischemia are poorly understood. The present studies examined the hypothesis that potassium channels are activated as an early response to hypoxia and contribute to potassium loss independent from an inhibition of active K+ uptake. Potassium flux in suspensions of freshly isolated rat proximal tubules was measured using an ion-selective electrode. Exposure of the tubules to hypoxia for only 2.5 min resulted in a rise in the passive leak rate of K+ but no decrease in active K+ uptake. The passive leak of K+ was associated with a 40% decrease in cell ATP content. The passive K+ efflux was inhibited by 5 mM Ba2+ (95%) and by 15 mM tetraethylammonium (85%) suggesting that K+ channels were the primary route of K+ movement. The effects of K+ channel blockade on the development of hypoxic injury were also examined. Tetraethylammonium and glibenclamide, an inhibitor of ATP-sensitive K+ channels, reduced hypoxic injury as assessed by the release of lactate dehydrogenase or measurement of DNA damage. These results suggest that activation of K+ channels is an early response to hypoxia and contributes to hypoxic renal injury. |Adenosine Triphosphate/analysis[MESH] |Animals[MESH] |Biological Transport[MESH] |DNA Damage[MESH] |Diazoxide/pharmacology[MESH] |Dose-Response Relationship, Drug[MESH] |Glyburide/pharmacology[MESH] |Hypoxia/*metabolism[MESH] |Ischemia/metabolism[MESH] |Kidney Diseases/metabolism[MESH] |Kidney Tubules, Proximal/drug effects/*metabolism[MESH] |Potassium Channels/*metabolism[MESH] |Potassium/*metabolism[MESH] |Rats[MESH] |Tetraethylammonium[MESH]Activation of potassium channels contributes to hypoxic injury in prox(epmc).pdf DeepDyve Pubget Overpricing