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10.1681/ASN.V641151 http://scihub22266oqcxt.onion/10.1681/ASN.V641151 8589281!ä!8589281 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\8589281.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Soc+Nephrol 1995 ; 6 (4): 1151-9 Nephropedia Template TP {{tp|p=8589281|t=1995. Epithelial tubulogenesis through branching morphogenesis: relevance to collecting system development |pdf=|usr=}}{{8589281}} gab.com Text Epithelial tubulogenesis through branching morphogenesis: relevance to collecting system development JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=8589281 #FOAvip Branching tubulogenesis of the ureteric bud, which gives rise to the urinary collecting system, is of considerable clinical interest because this process plays a major role in determining nephron number in the kidney. Data from in vitro model systems, including organ culture of the embryonic kidney and renal epithelial cells cultured in three-dimensional collagen matrices, indicate that growth factors, extracellular matrix composition, matrix-remodeling proteinases, and integrin expression are important factors in tubulogenesis and branching in the renal epithelium. One possibility is that gradients of soluble factors in the interstitial milieu of the embryonic kidney regulate the directionality of tubulogenesis and the degree of branching. Growth factors that enhance branching also appear to up-regulate matrix-remodeling extracellular proteinases. Redundancy in the ability of growth factors to induce tubulogenesis and branching may explain the apparent lack of a renal phenotype observed in targeted growth factor gene deletion experiments in mice. At the same time, differential effects in the efficiency of growth factors in inducing branching and/or changes in local matrix composition may be important in regulating the degree of arborization of the developing collecting system. Twit Text FOAVip Epithelial tubulogenesis through branching morphogenesis: relevance to collecting system development ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=8589281 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8589281 #FOAvip English Wikipedia <ref>{{Cite pmid|8589281}}</ref> Epithelial tubulogenesis through branching morphogenesis: relevance to collecting system development #MMPMID8589281 Stuart RO; Barros EJ; Ribeiro E; Nigam SK J Am Soc Nephrol 1995[Oct]; 6 (4): 1151-9 PMID8589281show ga Branching tubulogenesis of the ureteric bud, which gives rise to the urinary collecting system, is of considerable clinical interest because this process plays a major role in determining nephron number in the kidney. Data from in vitro model systems, including organ culture of the embryonic kidney and renal epithelial cells cultured in three-dimensional collagen matrices, indicate that growth factors, extracellular matrix composition, matrix-remodeling proteinases, and integrin expression are important factors in tubulogenesis and branching in the renal epithelium. One possibility is that gradients of soluble factors in the interstitial milieu of the embryonic kidney regulate the directionality of tubulogenesis and the degree of branching. Growth factors that enhance branching also appear to up-regulate matrix-remodeling extracellular proteinases. Redundancy in the ability of growth factors to induce tubulogenesis and branching may explain the apparent lack of a renal phenotype observed in targeted growth factor gene deletion experiments in mice. At the same time, differential effects in the efficiency of growth factors in inducing branching and/or changes in local matrix composition may be important in regulating the degree of arborization of the developing collecting system. |Animals[MESH] |Cell Line[MESH] |Embryonic and Fetal Development[MESH] |Endopeptidases/metabolism[MESH] |Extracellular Matrix/metabolism[MESH] |Growth Substances/pharmacology/physiology[MESH] |Humans[MESH] |Kidney Tubules, Collecting/*embryology[MESH] |Kidney Tubules/*embryology[MESH]Epithelial tubulogenesis through branching morphogenesis: relevance to(epmc).pdf DeepDyve Pubget Overpricing