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10.1084/jem.20071365 http://scihub22266oqcxt.onion/10.1084/jem.20071365 C2442640!2442640!18591406     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18591406&cmd=llinks): Failed to open stream: HTTP request failed! 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Clearance of influenza virus from the lung depends on migratory langerin+CD11b? but not plasmacytoid dendritic cells |pdf=|usr=}}{{18591406}} gab.com Text Clearance of influenza virus from the lung depends on migratory langerin+CD11b but not plasmacytoid dendritic cells JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=18591406 #FOAvip Although dendritic cells (DCs) play an important role in mediating protection against influenza virus, the precise role of lung DC subsets, such as CD11b? and CD11b+ conventional DCs or plasmacytoid DCs (pDCs), in different lung compartments is currently unknown. Early after intranasal infection, tracheal CD11b?CD11chi DCs migrated to the mediastinal lymph nodes (MLNs), acquiring co-stimulatory molecules in the process. This emigration from the lung was followed by an accumulation of CD11b+CD11chi DCs in the trachea and lung interstitium. In the MLNs, the CD11b+ DCs contained abundant viral nucleoprotein (NP), but these cells failed to present antigen to CD4 or CD8 T cells, whereas resident CD11b?CD8?+ DCs presented to CD8 cells, and migratory CD11b?CD8?? DCs presented to CD4 and CD8 T cells. When lung CD11chi DCs and macrophages or langerin+CD11b?CD11chi DCs were depleted using either CD11c?diphtheria toxin receptor (DTR) or langerin-DTR mice, the development of virus-specific CD8+ T cells was severely delayed, which correlated with increased clinical severity and a delayed viral clearance. 120G8+ CD11cint pDCs also accumulated in the lung and LNs carrying viral NP, but in their absence, there was no effect on viral clearance or clinical severity. Rather, in pDC-depleted mice, there was a reduction in antiviral antibody production after lung clearance of the virus. This suggests that multiple DCs are endowed with different tasks in mediating protection against influenza virus. Twit Text FOAVip Clearance of influenza virus from the lung depends on migratory langerin+CD11b but not plasmacytoid dendritic cells ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=18591406 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18591406 #FOAvip English Wikipedia <ref>{{Cite pmid|18591406}}</ref> Clearance of influenza virus from the lung depends on migratory langerin+CD11b? but not plasmacytoid dendritic cells #MMPMID18591406 GeurtsvanKessel CH; Willart MA; van Rijt LS; Muskens F; Kool M; Baas C; Thielemans K; Bennett C; Clausen BE; Hoogsteden HC; Osterhaus AD; Rimmelzwaan GF; Lambrecht BN J Exp Med 2008[Jul]; 205 (7): 1621-34 PMID18591406show ga Although dendritic cells (DCs) play an important role in mediating protection against influenza virus, the precise role of lung DC subsets, such as CD11b? and CD11b+ conventional DCs or plasmacytoid DCs (pDCs), in different lung compartments is currently unknown. Early after intranasal infection, tracheal CD11b?CD11chi DCs migrated to the mediastinal lymph nodes (MLNs), acquiring co-stimulatory molecules in the process. This emigration from the lung was followed by an accumulation of CD11b+CD11chi DCs in the trachea and lung interstitium. In the MLNs, the CD11b+ DCs contained abundant viral nucleoprotein (NP), but these cells failed to present antigen to CD4 or CD8 T cells, whereas resident CD11b?CD8?+ DCs presented to CD8 cells, and migratory CD11b?CD8?? DCs presented to CD4 and CD8 T cells. When lung CD11chi DCs and macrophages or langerin+CD11b?CD11chi DCs were depleted using either CD11c?diphtheria toxin receptor (DTR) or langerin-DTR mice, the development of virus-specific CD8+ T cells was severely delayed, which correlated with increased clinical severity and a delayed viral clearance. 120G8+ CD11cint pDCs also accumulated in the lung and LNs carrying viral NP, but in their absence, there was no effect on viral clearance or clinical severity. Rather, in pDC-depleted mice, there was a reduction in antiviral antibody production after lung clearance of the virus. This suggests that multiple DCs are endowed with different tasks in mediating protection against influenza virus. äClearance of influenza virus from the lung depends on migratory langer(epmc).pdf DeepDyve Pubget Overpricing