Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1089/ars.2010.3549 http://scihub22266oqcxt.onion/10.1089/ars.2010.3549 C3078500!3078500!20812867     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20812867&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20812867.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Antioxid+Redox+Signal 2011 ; 14 (10): 1815-27 Nephropedia Template TP {{tp|p=20812867|t=2011. Pathophysiologically Relevant Levels of Hydrogen Peroxide Induce Glutamate-Independent Neurodegeneration That Involves Activation of Transient Receptor Potential Melastatin 7 Channels |pdf=|usr=}}{{20812867}} gab.com Text Pathophysiologically Relevant Levels of Hydrogen Peroxide Induce Glutamate-Independent Neurodegeneration That Involves Activation of Transient Receptor Potential Melastatin 7 Channels JO: Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=20812867 #FOAvip Stroke/brain ischemia is a leading cause of death and long-term disabilities. Increased oxidative stress plays an important role in the pathology of brain ischemia. Hydrogen peroxide (H2O2) is a major oxidant known to cause neuronal injury; however, the detailed mechanism remains unclear. Previous studies have suggested that H2O2-induced injury is associated with increased intracellular Ca2+, mediated by glutamate receptors or voltage-gated Ca2+ channels. Here, we demonstrate that, at concentrations relevant to stroke, H2O2 induces a Ca2+-dependent injury of mouse cortical neurons in the absence of activation of these receptors/channels. With the culture medium containing blockers of glutamate receptors and voltage-gated Ca2+ channels, brief exposure of neurons to H2O2 induced a dose-dependent injury. Reducing [Ca2+]e inhibited whereas increasing [Ca2+]e potentiated the H2O2 injury. Fluorescent Ca2+ imaging confirmed the increase of [Ca2+]i by H2O2 in the presence of the blockers of glutamate receptors and voltage-gated Ca2+ channels. Addition of 2-aminoethoxydiphenyl borate, an inhibitor of transient receptor potential melastatin 7 (TRPM7) channels, or the use of TRPM7-small interference RNA, protected the neurons from H2O2 injury. In contrast, overexpressing TRPM7 channels in human embryonic kidney 293 cells increased H2O2 injury. Our findings indicate that H2O2 can induce Ca2+ toxicity independent of glutamate receptors and voltage-gated Ca2+ channels. Activation of TRPM7 channels is involved in such toxicity. Antioxid. Redox Signal. 14, 1815?1827. Twit Text FOAVip Pathophysiologically Relevant Levels of Hydrogen Peroxide Induce Glutamate-Independent Neurodegeneration That Involves Activation of Transient Receptor Potential Melastatin 7 Channels ????Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=20812867 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20812867 #FOAvip English Wikipedia <ref>{{Cite pmid|20812867}}</ref> Pathophysiologically Relevant Levels of Hydrogen Peroxide Induce Glutamate-Independent Neurodegeneration That Involves Activation of Transient Receptor Potential Melastatin 7 Channels #MMPMID20812867 Coombes E; Jiang J; Chu XP; Inoue K; Seeds J; Branigan D; Simon RP; Xiong ZG Antioxid Redox Signal 2011[May]; 14 (10): 1815-27 PMID20812867show ga Stroke/brain ischemia is a leading cause of death and long-term disabilities. Increased oxidative stress plays an important role in the pathology of brain ischemia. Hydrogen peroxide (H2O2) is a major oxidant known to cause neuronal injury; however, the detailed mechanism remains unclear. Previous studies have suggested that H2O2-induced injury is associated with increased intracellular Ca2+, mediated by glutamate receptors or voltage-gated Ca2+ channels. Here, we demonstrate that, at concentrations relevant to stroke, H2O2 induces a Ca2+-dependent injury of mouse cortical neurons in the absence of activation of these receptors/channels. With the culture medium containing blockers of glutamate receptors and voltage-gated Ca2+ channels, brief exposure of neurons to H2O2 induced a dose-dependent injury. Reducing [Ca2+]e inhibited whereas increasing [Ca2+]e potentiated the H2O2 injury. Fluorescent Ca2+ imaging confirmed the increase of [Ca2+]i by H2O2 in the presence of the blockers of glutamate receptors and voltage-gated Ca2+ channels. Addition of 2-aminoethoxydiphenyl borate, an inhibitor of transient receptor potential melastatin 7 (TRPM7) channels, or the use of TRPM7-small interference RNA, protected the neurons from H2O2 injury. In contrast, overexpressing TRPM7 channels in human embryonic kidney 293 cells increased H2O2 injury. Our findings indicate that H2O2 can induce Ca2+ toxicity independent of glutamate receptors and voltage-gated Ca2+ channels. Activation of TRPM7 channels is involved in such toxicity. Antioxid. Redox Signal. 14, 1815?1827. �Pathophysiologically Relevant Levels of Hydrogen Peroxide Induce Gluta(epmc).pdf DeepDyve Pubget Overpricing