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Resolution of immune response by recombinant transforming growth factor-beta (rTGF-?) during influenza A virus infection |pdf=|usr=}}{{23168705}} gab.com Text Resolution of immune response by recombinant transforming growth factor-beta (rTGF- ) during influenza A virus infection JO: Indian J Med Res http://www.kidney.de/pget.php?&tw=1&pmid=23168705 #FOAvip Background & objectives:: Replication of influenza A virus in the respiratory tract leads to cell damage and liberation of cytokines and chemokines. The in vivo cytokine induction and modulation by recombinant transforming growth factor- ?1 (rTGF-?1) has not been studied. Therefore, in the present study the effect of rTGF-?1, a potent immunomodulatory cytokine which has anti-inflammatory properties and downregulates the release of inflammatory molecules, against influenza-virus infection in the airway of mice was investigated. Methods:: rTGF-?1 was administered intravenously to mice with concomitant intranasal infection of influenza A/Udorn/317/72 (H3N2) virus, and the survival rate, virus titre, histopathological changes and levels of factors regulating inflammation in the airway fluid were analysed. Result:: The immune response to influenza A virus was characterized by an influx of both macrophages and lymphocytes into the lungs of the infected host. rTGF-?1 significantly suppressed virus multiplication and improved the survival rate of mice. rTGF-?1 downregulated infiltration of neutrophils and the release of inflammatory molecules, such as interferon-gamma (IFN-?), interleukin-1 ? (IL-1?) and stimulated release of IL-10 that potentiates anti-inflammatory response into airway. Interpretation & conclusions:: A generalized pulmonary inflammation does not contribute to viral clearance but represents an immunological background within which antiviral immunity operates. Treatment with rTGF-?1 reduced macrophage count and neutrophils influx in lungs of infected mice. Twit Text FOAVip Resolution of immune response by recombinant transforming growth factor-beta (rTGF- ) during influenza A virus infection ????Indian J Med Res http://www.kidney.de/pget.php?&tw=1&pmid=23168705 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23168705 #FOAvip English Wikipedia <ref>{{Cite pmid|23168705}}</ref> Resolution of immune response by recombinant transforming growth factor-beta (rTGF-?) during influenza A virus infection #MMPMID23168705 Srivastava V; Khanna M; Sharma S; Kumar B Indian J Med Res 2012[Oct]; 136 (4): 641-8 PMID23168705show ga Background & objectives:: Replication of influenza A virus in the respiratory tract leads to cell damage and liberation of cytokines and chemokines. The in vivo cytokine induction and modulation by recombinant transforming growth factor- ?1 (rTGF-?1) has not been studied. Therefore, in the present study the effect of rTGF-?1, a potent immunomodulatory cytokine which has anti-inflammatory properties and downregulates the release of inflammatory molecules, against influenza-virus infection in the airway of mice was investigated. Methods:: rTGF-?1 was administered intravenously to mice with concomitant intranasal infection of influenza A/Udorn/317/72 (H3N2) virus, and the survival rate, virus titre, histopathological changes and levels of factors regulating inflammation in the airway fluid were analysed. Result:: The immune response to influenza A virus was characterized by an influx of both macrophages and lymphocytes into the lungs of the infected host. rTGF-?1 significantly suppressed virus multiplication and improved the survival rate of mice. rTGF-?1 downregulated infiltration of neutrophils and the release of inflammatory molecules, such as interferon-gamma (IFN-?), interleukin-1 ? (IL-1?) and stimulated release of IL-10 that potentiates anti-inflammatory response into airway. Interpretation & conclusions:: A generalized pulmonary inflammation does not contribute to viral clearance but represents an immunological background within which antiviral immunity operates. Treatment with rTGF-?1 reduced macrophage count and neutrophils influx in lungs of infected mice. äResolution of immune response by recombinant transforming growth facto(epmc).pdf DeepDyve Pubget Overpricing