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10.1074/jbc.M112.393918

http://scihub22266oqcxt.onion/10.1074/jbc.M112.393918
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C3537020!3537020!23168410
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suck abstract from ncbi


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pmid23168410      J+Biol+Chem 2013 ; 288 (1): 255-63
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  • Increase in Serum Ca2+/Mg2+ Ratio Promotes Proliferation of Prostate Cancer Cells by Activating TRPM7 Channels* #MMPMID23168410
  • Sun Y; Selvaraj S; Varma A; Derry S; Sahmoun AE; Singh BB
  • J Biol Chem 2013[Jan]; 288 (1): 255-63 PMID23168410show ga
  • Background: Mg2+ concentration regulates MagNuM channels; however, their role in prostate cancer is not known.Results: TRPM7 functions as an endogenous MagNuM channel, which facilitates Ca2+ entry at low Mg2+ levels and promotes cell proliferation.Conclusion: Alteration in Ca2+/Mg2+ ratio could lead to prostate cancer.Significance: Learning how extra/intracellular Ca2+/Mg2+ ratio is regulated is crucial for understanding and/or diagnosis of prostate cancer.
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