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10.4049/jimmunol.1203302 http://scihub22266oqcxt.onion/10.4049/jimmunol.1203302 C3703618!3703618!23667113     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23667113&cmd=llinks): Failed to open stream: HTTP request failed! 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Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice |pdf=|usr=}}{{23667113}} gab.com Text Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23667113 #FOAvip We have examined the formation, participation and functional specialization of virus-reactive Foxp3+ regulatory T cells (Tregs) in a mouse model of influenza virus infection. ?Natural? Tregs generated intra-thymically based on interactions with a self-peptide proliferated in response to a homologous viral antigen in the lungs, and to a lesser extent in the lung-draining mediastinal LN (medLN), of virus-infected mice. By contrast, conventional CD4+ T cells with identical TCR specificity underwent little or no conversion to become ?adaptive? Tregs. The virus-reactive Tregs in the medLN and the lungs of infected mice upregulated a variety of molecules associated with Treg activation, and also acquired expression of molecules (T-bet, Blimp-1 and IL-10) that confer functional specialization to Tregs. Notably, however, the phenotypes of the T-bet+ Tregs obtained from these sites were distinct, since Tregs isolated from the lungs expressed significantly higher levels of T-bet, Blimp-1 and IL-10 than did Tregs from the medLN. Adoptive transfer of antigen-reactive Tregs led to decreased proliferation of anti-viral CD4+ and CD8+ effector T cells in the lungs of infected hosts, while depletion of Tregs had a reciprocal effect. These studies demonstrate that thymically-generated Tregs can become activated by a pathogen-derived peptide and acquire discrete T-bet+ Treg phenotypes while participating in and modulating an antiviral immune response. Twit Text FOAVip Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23667113 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23667113 #FOAvip English Wikipedia <ref>{{Cite pmid|23667113}}</ref> Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice #MMPMID23667113 Bedoya F; Cheng GS; Leibow A; Zakhary N; Weissler K; Garcia V; Aitken M; Kropf E; Garlick DS; Wherry EJ; Erikson J; Caton nJ J Immunol 2013[Jun]; 190 (12): 6115-25 PMID23667113show ga We have examined the formation, participation and functional specialization of virus-reactive Foxp3+ regulatory T cells (Tregs) in a mouse model of influenza virus infection. ?Natural? Tregs generated intra-thymically based on interactions with a self-peptide proliferated in response to a homologous viral antigen in the lungs, and to a lesser extent in the lung-draining mediastinal LN (medLN), of virus-infected mice. By contrast, conventional CD4+ T cells with identical TCR specificity underwent little or no conversion to become ?adaptive? Tregs. The virus-reactive Tregs in the medLN and the lungs of infected mice upregulated a variety of molecules associated with Treg activation, and also acquired expression of molecules (T-bet, Blimp-1 and IL-10) that confer functional specialization to Tregs. Notably, however, the phenotypes of the T-bet+ Tregs obtained from these sites were distinct, since Tregs isolated from the lungs expressed significantly higher levels of T-bet, Blimp-1 and IL-10 than did Tregs from the medLN. Adoptive transfer of antigen-reactive Tregs led to decreased proliferation of anti-viral CD4+ and CD8+ effector T cells in the lungs of infected hosts, while depletion of Tregs had a reciprocal effect. These studies demonstrate that thymically-generated Tregs can become activated by a pathogen-derived peptide and acquire discrete T-bet+ Treg phenotypes while participating in and modulating an antiviral immune response. äViral antigen induces differentiation of Foxp3+ natural regulatory T c(epmc).pdf DeepDyve Pubget Overpricing