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10.1111/j.1582-4934.2009.00977.x http://scihub22266oqcxt.onion/10.1111/j.1582-4934.2009.00977.x C3837620!3837620!19929944     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19929944.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2010 ; 14 (1-2): 181-97 Nephropedia Template TP {{tp|p=19929944|t=2010. A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory |pdf=|usr=}}{{19929944}} gab.com Text A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=19929944 #FOAvip Lynch syndrome (LS) is caused by mutations in mismatch repair genes and is characterized by a high cumulative risk for the development of mainly colorectal carcinoma and endometrial carcinoma. Early detection of LS is important since surveillance can reduce morbidity and mortality. However, the diagnosis of LS is complicated by the absence of a pre-morbid phenotype and germline mutation analysis is expensive and time consuming. Therefore it is standard practice to precede germline mutation analysis by a molecular diagnostic work-up of tumours, guided by clinical and pathological criteria, to select patients for germline mutation analysis. In this review we address these molecular analyses, the central role for the pathologist in the selection of patients for germline diagnostics of LS, as well as the molecular basis of LS. Twit Text FOAVip A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=19929944 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19929944 #FOAvip English Wikipedia <ref>{{Cite pmid|19929944}}</ref> A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory #MMPMID19929944 Van Lier MG; Wagner A; Van Leerdam ME; Biermann K; Kuipers EJ; Steyerberg EW; Dubbink HJ; Dinjens WN J Cell Mol Med 2010[Jan]; 14 (1-2): 181-97 PMID19929944show ga Lynch syndrome (LS) is caused by mutations in mismatch repair genes and is characterized by a high cumulative risk for the development of mainly colorectal carcinoma and endometrial carcinoma. Early detection of LS is important since surveillance can reduce morbidity and mortality. However, the diagnosis of LS is complicated by the absence of a pre-morbid phenotype and germline mutation analysis is expensive and time consuming. Therefore it is standard practice to precede germline mutation analysis by a molecular diagnostic work-up of tumours, guided by clinical and pathological criteria, to select patients for germline mutation analysis. In this review we address these molecular analyses, the central role for the pathologist in the selection of patients for germline diagnostics of LS, as well as the molecular basis of LS. äA review on the molecular diagnostics of Lynch syndrome: a central rol(epmc).pdf DeepDyve Pubget Overpricing