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10.3390/biom1010032 http://scihub22266oqcxt.onion/10.3390/biom1010032 C4030829!4030829!24970122     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24970122&cmd=llinks): Failed to open stream: HTTP request failed! 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Ursolic Acid Inhibits Na+/K+-ATPase Activity and Prevents TNF-?-Induced Gene Expression by Blocking Amino Acid Transport and Cellular Protein Synthesis |pdf=|usr=}}{{24970122}} gab.com Text Ursolic Acid Inhibits Na+/K+-ATPase Activity and Prevents TNF- -Induced Gene Expression by Blocking Amino Acid Transport and Cellular Protein Synthesis JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=24970122 #FOAvip Pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-?, induce the expression of a wide variety of genes, including intercellular adhesion molecule-1 (ICAM-1). Ursolic acid (3?-hydroxy-urs-12-en-28-oic acid) was identified to inhibit the cell-surface ICAM-1 expression induced by pro-inflammatory cytokines in human lung carcinoma A549 cells. Ursolic acid was found to inhibit the TNF-?-induced ICAM-1 protein expression almost completely, whereas the TNF-?-induced ICAM-1 mRNA expression and NF-?B signaling pathway were decreased only partially by ursolic acid. In line with these findings, ursolic acid prevented cellular protein synthesis as well as amino acid uptake, but did not obviously affect nucleoside uptake and the subsequent DNA/RNA syntheses. This inhibitory profile of ursolic acid was similar to that of the Na+/K+-ATPase inhibitor, ouabain, but not the translation inhibitor, cycloheximide. Consistent with this notion, ursolic acid was found to inhibit the catalytic activity of Na+/K+-ATPase. Thus, our present study reveals a novel molecular mechanism in which ursolic acid inhibits Na+/K+-ATPase activity and prevents the TNF-?-induced gene expression by blocking amino acid transport and cellular protein synthesis. Twit Text FOAVip Ursolic Acid Inhibits Na+/K+-ATPase Activity and Prevents TNF- -Induced Gene Expression by Blocking Amino Acid Transport and Cellular Protein Synthesis ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=24970122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24970122 #FOAvip English Wikipedia <ref>{{Cite pmid|24970122}}</ref> Ursolic Acid Inhibits Na+/K+-ATPase Activity and Prevents TNF-?-Induced Gene Expression by Blocking Amino Acid Transport and Cellular Protein Synthesis #MMPMID24970122 Yokomichi T; Morimoto K; Oshima N; Yamada Y; Fu L; Taketani S; Ando M; Kataoka T Biomolecules 2011[Dec]; 1 (1): 32-47 PMID24970122show ga Pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-?, induce the expression of a wide variety of genes, including intercellular adhesion molecule-1 (ICAM-1). Ursolic acid (3?-hydroxy-urs-12-en-28-oic acid) was identified to inhibit the cell-surface ICAM-1 expression induced by pro-inflammatory cytokines in human lung carcinoma A549 cells. Ursolic acid was found to inhibit the TNF-?-induced ICAM-1 protein expression almost completely, whereas the TNF-?-induced ICAM-1 mRNA expression and NF-?B signaling pathway were decreased only partially by ursolic acid. In line with these findings, ursolic acid prevented cellular protein synthesis as well as amino acid uptake, but did not obviously affect nucleoside uptake and the subsequent DNA/RNA syntheses. This inhibitory profile of ursolic acid was similar to that of the Na+/K+-ATPase inhibitor, ouabain, but not the translation inhibitor, cycloheximide. Consistent with this notion, ursolic acid was found to inhibit the catalytic activity of Na+/K+-ATPase. Thus, our present study reveals a novel molecular mechanism in which ursolic acid inhibits Na+/K+-ATPase activity and prevents the TNF-?-induced gene expression by blocking amino acid transport and cellular protein synthesis. äUrsolic Acid Inhibits Na+/K+-ATPase Activity and Prevents TNF-?-Induce(epmc).pdf DeepDyve Pubget Overpricing