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10.1038/cddis.2014.172 http://scihub22266oqcxt.onion/10.1038/cddis.2014.172 C4047894!4047894!24810049     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24810049&cmd=llinks): Failed to open stream: HTTP request failed! 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Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-?B activation via a negative feedback loop |pdf=|usr=}}{{24810049}} gab.com Text Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF- B activation via a negative feedback loop JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=24810049 #FOAvip CD40-induced signalling through ligation with its natural ligand (CD40L/CD154) is dependent on recruitment of TRAF molecules to the cytoplasmic domain of the receptor. Here, we applied the yeast two-hybrid system to examine whether other proteins can interact with CD40. Fas-Associated Factor 1(FAF1) was isolated from a HeLa cDNA library using the CD40 cytoplasmic tail (216?278 aa) as a bait construct. FAF1 was able to interact with CD40 both in vitro and in vivo. The FAF1 N-terminal domain was sufficient to bind CD40 and required the TRAF6-binding domain within the cytoplasmic tail of CD40 for binding. CD40 ligation induced FAF1 expression in an NF?B-dependent manner. Knockdown of FAF1 prolonged CD40-induced NF?B, whereas overexpression of FAF1 suppressed CD40-induced NF?B activity and this required interaction of FAF1 with the CD40 receptor via its FID domain. Thus, we report a novel role for FAF1in regulating CD40-induced NF?B activation via a negative feedback loop. Loss of FAF1 function in certain human malignancies may contribute to oncogenesis through unchecked NF?B activation, and further understanding of this process may provide a biomarker of NF?B-targeted therapies for such malignancies. Twit Text FOAVip Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF- B activation via a negative feedback loop ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=24810049 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24810049 #FOAvip English Wikipedia <ref>{{Cite pmid|24810049}}</ref> Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-?B activation via a negative feedback loop #MMPMID24810049 Elmetwali T; Young LS; Palmer DH Cell Death Dis 2014[May]; 5 (5): e1213- PMID24810049show ga CD40-induced signalling through ligation with its natural ligand (CD40L/CD154) is dependent on recruitment of TRAF molecules to the cytoplasmic domain of the receptor. Here, we applied the yeast two-hybrid system to examine whether other proteins can interact with CD40. Fas-Associated Factor 1(FAF1) was isolated from a HeLa cDNA library using the CD40 cytoplasmic tail (216?278 aa) as a bait construct. FAF1 was able to interact with CD40 both in vitro and in vivo. The FAF1 N-terminal domain was sufficient to bind CD40 and required the TRAF6-binding domain within the cytoplasmic tail of CD40 for binding. CD40 ligation induced FAF1 expression in an NF?B-dependent manner. Knockdown of FAF1 prolonged CD40-induced NF?B, whereas overexpression of FAF1 suppressed CD40-induced NF?B activity and this required interaction of FAF1 with the CD40 receptor via its FID domain. Thus, we report a novel role for FAF1in regulating CD40-induced NF?B activation via a negative feedback loop. Loss of FAF1 function in certain human malignancies may contribute to oncogenesis through unchecked NF?B activation, and further understanding of this process may provide a biomarker of NF?B-targeted therapies for such malignancies. äFas-associated factor (Faf1) is a novel CD40 interactor that regulates(epmc).pdf DeepDyve Pubget Overpricing