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10.1186/1471-2369-15-87 http://scihub22266oqcxt.onion/10.1186/1471-2369-15-87 C4064102!4064102!24912660     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24912660&cmd=llinks): Failed to open stream: HTTP request failed! 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Cardiovascular disease relates to intestinal uptake of p-cresol in patients with chronic kidney disease |pdf=|usr=}}{{24912660}} gab.com Text Cardiovascular disease relates to intestinal uptake of p-cresol in patients with chronic kidney disease JO: BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24912660 #FOAvip Background: Serum p-cresyl sulfate (PCS) associates with cardiovascular disease in patients with chronic kidney disease. PCS concentrations are determined by intestinal uptake of p-cresol, human metabolism to PCS and renal clearance. Whether intestinal uptake of p-cresol itself is directly associated with cardiovascular disease in patients with renal dysfunction has not been studied to date. Methods: We performed a prospective study in patients with chronic kidney disease stage 1 ? 5 (NCT00441623). Intestinal uptake of p-cresol, under steady state conditions, was estimated from 24 h urinary excretion of PCS. Primary endpoint was time to first cardiovascular event, i.e., cardiac death, myocardial infarction/ischemia, ventricular arrhythmia, cardiovascular surgery, ischemic stroke or symptomatic peripheral arterial disease. Statistical analysis was done using Kaplan-Meier estimates and Cox proportional hazard analyses. Results: In a cohort of 200 patients, median 24 h urinary excretion of PCS amounted to 457.47 ?mol (IQR 252.68 ? 697.17). After a median follow-up of 52 months, 25 patients reached the primary endpoint (tertile 1/2/3: 5/6/14 events, log rank P 0.037). Higher urinary excretion of PCS was directly associated with cardiovascular events (univariate hazard ratio per 100 ?mol increase: 1.112, P 0.002). In multivariate analysis, urinary excretion of PCS remained a predictor of cardiovascular events, independent of eGFR (hazard ratio 1.120, P 0.002). Conclusions: In patients with chronic kidney disease, intestinal uptake of p-cresol associates with cardiovascular disease independent of renal function. The intestinal generation and absorption of p-cresol may be therapeutic targets to reduce cardiovascular disease risk in patients with renal dysfunction. Twit Text FOAVip Cardiovascular disease relates to intestinal uptake of p-cresol in patients with chronic kidney disease ????BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24912660 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24912660 #FOAvip English Wikipedia <ref>{{Cite pmid|24912660}}</ref> Cardiovascular disease relates to intestinal uptake of p-cresol in patients with chronic kidney disease #MMPMID24912660 Poesen R; Viaene L; Verbeke K; Augustijns P; Bammens B; Claes K; Kuypers D; Evenepoel P; Meijers B BMC Nephrol 2014[]; 15 (ä): 87 PMID24912660show ga Background: Serum p-cresyl sulfate (PCS) associates with cardiovascular disease in patients with chronic kidney disease. PCS concentrations are determined by intestinal uptake of p-cresol, human metabolism to PCS and renal clearance. Whether intestinal uptake of p-cresol itself is directly associated with cardiovascular disease in patients with renal dysfunction has not been studied to date. Methods: We performed a prospective study in patients with chronic kidney disease stage 1 ? 5 (NCT00441623). Intestinal uptake of p-cresol, under steady state conditions, was estimated from 24 h urinary excretion of PCS. Primary endpoint was time to first cardiovascular event, i.e., cardiac death, myocardial infarction/ischemia, ventricular arrhythmia, cardiovascular surgery, ischemic stroke or symptomatic peripheral arterial disease. Statistical analysis was done using Kaplan-Meier estimates and Cox proportional hazard analyses. Results: In a cohort of 200 patients, median 24 h urinary excretion of PCS amounted to 457.47 ?mol (IQR 252.68 ? 697.17). After a median follow-up of 52 months, 25 patients reached the primary endpoint (tertile 1/2/3: 5/6/14 events, log rank P 0.037). Higher urinary excretion of PCS was directly associated with cardiovascular events (univariate hazard ratio per 100 ?mol increase: 1.112, P 0.002). In multivariate analysis, urinary excretion of PCS remained a predictor of cardiovascular events, independent of eGFR (hazard ratio 1.120, P 0.002). Conclusions: In patients with chronic kidney disease, intestinal uptake of p-cresol associates with cardiovascular disease independent of renal function. The intestinal generation and absorption of p-cresol may be therapeutic targets to reduce cardiovascular disease risk in patients with renal dysfunction. äCardiovascular disease relates to intestinal uptake of p-cresol in pat(epmc).pdf DeepDyve Pubget Overpricing