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BONE MARROW-DERIVED STROMAL CELL THERAPY IN CIRRHOSIS: CLINICAL EVIDENCE, CELLULAR MECHANISMS AND IMPLICATIONS FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA #MMPMID24969793
Vainshtein JM; Kabarriti R; Mehta KJ; Roy-Chowdhury J; Guha C
Int J Radiat Oncol Biol Phys 2014[Jul]; 89 (4): 786-803 PMID24969793show ga
Hepatocellular carcinoma (HCC) is the 5th most common malignancy worldwide and accounts for nearly 10% of cancer deaths annually [1]. In patients with well-preserved liver function and limited disease, surgical resection offers the best chance of cure. For the 80% of HCC patients with underlying cirrhosis, however, liver transplantation remains the only available curative treatment, and then only in Child-Pugh (C-P) class A or B patients [1]. Even in transplant-eligible patients, the shortage of available donor livers severely limits the number of HCC patients that ultimately undergo transplantation [2]. Thus, for the majority of HCC patients, which present at advanced stage or with significant liver dysfunction, non-surgical interventions remain the only treatment option [1].