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10.1016/j.chom.2014.06.008 http://scihub22266oqcxt.onion/10.1016/j.chom.2014.06.008 C4159752!4159752!25011106     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25011106&cmd=llinks): Failed to open stream: HTTP request failed! 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Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases |pdf=|usr=}}{{25011106}} gab.com Text Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=25011106 #FOAvip Measles virus (MV) is highly infectious and infects dendritic cells (DCs) for viral dissemination. DCs express RIG-I-like receptors (RLRs) RIG-I and Mda5 that sense MV to induce antiviral type I interferon (IFN) responses. Dephosphorylation of RIG-I and Mda5 by PP1 phosphatases is required for their activation. Here we demonstrate that MV suppresses RIG-I and Mda5 dephosphorylation via DC-SIGN signaling. MV binding to DC-SIGN leads to activation of kinase Raf-1, which induced association of the PP1 inhibitor I-1 with GADD34-PP1 holoenzymes, thereby inhibiting the phosphatase activity. As a result, GADD34-PP1 holoenzymes were unable to dephosphorylate RIG-I and Mda5, hence suppressing type I IFN responses and enhancing MV replication. Interference with DC-SIGN signaling allowed activation of RLRs and subsequently suppressed MV infection of DCs. Thus, MV subverts DC-SIGN signaling, leading to inhibition of PP1 phosphatases that control RIG-I and Mda5 activation, which might be used by other viruses to escape antiviral responses. Twit Text FOAVip Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=25011106 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25011106 #FOAvip English Wikipedia <ref>{{Cite pmid|25011106}}</ref> Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases #MMPMID25011106 Mesman AW; Zijlstra-Willems EM; Kaptein TM; de Swart RL; Davis ME; Ludlow M; Duprex WP; Gack MU; Gringhuis SI; Geijtenbeek TB Cell Host Microbe 2014[Jul]; 16 (1): 31-42 PMID25011106show ga Measles virus (MV) is highly infectious and infects dendritic cells (DCs) for viral dissemination. DCs express RIG-I-like receptors (RLRs) RIG-I and Mda5 that sense MV to induce antiviral type I interferon (IFN) responses. Dephosphorylation of RIG-I and Mda5 by PP1 phosphatases is required for their activation. Here we demonstrate that MV suppresses RIG-I and Mda5 dephosphorylation via DC-SIGN signaling. MV binding to DC-SIGN leads to activation of kinase Raf-1, which induced association of the PP1 inhibitor I-1 with GADD34-PP1 holoenzymes, thereby inhibiting the phosphatase activity. As a result, GADD34-PP1 holoenzymes were unable to dephosphorylate RIG-I and Mda5, hence suppressing type I IFN responses and enhancing MV replication. Interference with DC-SIGN signaling allowed activation of RLRs and subsequently suppressed MV infection of DCs. Thus, MV subverts DC-SIGN signaling, leading to inhibition of PP1 phosphatases that control RIG-I and Mda5 activation, which might be used by other viruses to escape antiviral responses. äMeasles virus suppresses RIG-I-like receptor activation in dendritic c(epmc).pdf DeepDyve Pubget Overpricing