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10.1016/j.neurobiolaging.2014.05.016 http://scihub22266oqcxt.onion/10.1016/j.neurobiolaging.2014.05.016 C4171192!4171192!24973121     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24973121.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neurobiol+Aging 2014 ; 35 (11): 2458-64 Nephropedia Template TP {{tp|p=24973121|t=2014. Zileuton restores memory impairments and reverses amyloid and tau pathology in aged AD mice |pdf=|usr=}}{{24973121}} gab.com Text Zileuton restores memory impairments and reverses amyloid and tau pathology in aged AD mice JO: Neurobiol Aging http://www.kidney.de/pget.php?&tw=1&pmid=24973121 #FOAvip The enzyme 5-lipoxygenase (5LO) is up-regulated in Alzheimer?s disease (AD), and its pharmacological blockade with zileuton slows down the development of the AD-like phenotype in young AD mice. However, its efficacy after the AD pathology is established is unknown. To this end, starting at 12-months of age triple transgenic mice (3xTg) received zileuton, a selective 5LO inhibitor, or placebo for 3 months, and then the effect of this treatment on behavior, amyloid and tau pathology assessed. While mice on placebo showed worsening of their memory, treated mice performed even better than at baseline. Compared with placebo, treated mice had significant less A? deposits and tau phosphorylation secondary to reduced ?-secretase and CDK-5 activation, respectively. Our data provide novel insights into the disease-modifying action of pharmacologically inhibiting 5LO as a viable AD therapeutic approach. They represent the successful completion of preclinical studies for the development of this class of drug as clinically applicable therapy for the disease. Twit Text FOAVip Zileuton restores memory impairments and reverses amyloid and tau pathology in aged AD mice ????Neurobiol Aging http://www.kidney.de/pget.php?&tw=1&pmid=24973121 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24973121 #FOAvip English Wikipedia <ref>{{Cite pmid|24973121}}</ref> Zileuton restores memory impairments and reverses amyloid and tau pathology in aged AD mice #MMPMID24973121 Di Meco A; Lauretti E; Vagnozzi AN; Praticò D Neurobiol Aging 2014[Nov]; 35 (11): 2458-64 PMID24973121show ga The enzyme 5-lipoxygenase (5LO) is up-regulated in Alzheimer?s disease (AD), and its pharmacological blockade with zileuton slows down the development of the AD-like phenotype in young AD mice. However, its efficacy after the AD pathology is established is unknown. To this end, starting at 12-months of age triple transgenic mice (3xTg) received zileuton, a selective 5LO inhibitor, or placebo for 3 months, and then the effect of this treatment on behavior, amyloid and tau pathology assessed. While mice on placebo showed worsening of their memory, treated mice performed even better than at baseline. Compared with placebo, treated mice had significant less A? deposits and tau phosphorylation secondary to reduced ?-secretase and CDK-5 activation, respectively. Our data provide novel insights into the disease-modifying action of pharmacologically inhibiting 5LO as a viable AD therapeutic approach. They represent the successful completion of preclinical studies for the development of this class of drug as clinically applicable therapy for the disease. äZileuton restores memory impairments and reverses amyloid and tau path(epmc).pdf DeepDyve Pubget Overpricing