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10.1074/jbc.M114.590554

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suck abstract from ncbi


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pmid25112868      J+Biol+Chem 2014 ; 289 (39): 26847-58
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  • Heme Oxygenase-1 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis by Regulating Th17/Treg Cell Balance* #MMPMID25112868
  • Zhang L; Zhang Y; Zhong W; Di C; Lin X; Xia Z
  • J Biol Chem 2014[Sep]; 289 (39): 26847-58 PMID25112868show ga
  • Background: Heme oxygenase-1 (HO-1) is an inducible enzyme with pleiotropic immunomodulatory effects.Results: Induction of HO-1 inhibits Th17-mediated responses in experimental colitis and switches the naive T cells to Tregs under Th17-skewing conditions in vitro.Conclusion: HO-1 ameliorates dextran sulfate sodium (DSS)-induced colitis via blocking IL-6/IL-6R signaling to regulate Th17/Treg cell balance.Significance: HO-1 may become a novel therapeutic target in IBD.
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