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10.1074/jbc.M114.598763

http://scihub22266oqcxt.onion/10.1074/jbc.M114.598763
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suck abstract from ncbi


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pmid25107905      J+Biol+Chem 2014 ; 289 (39): 26960-72
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  • I?B Kinase ? (IKBKB) Mutations in Lymphomas That Constitutively Activate Canonical Nuclear Factor ?B (NF?B) Signaling* #MMPMID25107905
  • Kai X; Chellappa V; Donado C; Reyon D; Sekigami Y; Ataca D; Louissaint A; Mattoo H; Joung JK; Pillai S
  • J Biol Chem 2014[Sep]; 289 (39): 26960-72 PMID25107905show ga
  • Background: How I?B kinase? K171E and K171T mutations mediate lymphomagenesis is not known.Results: We performed biochemical, molecular modeling and TALEN-based knockin studies on wild-type and mutant IKK?.Conclusion: Mutant IKK? molecules are constitutively active in an activation-loop phosphorylation-independent manner.Significance: These results have broad implications for the function of positively charged residues in all activation loop-dependent kinases.
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